HTR1F
5-Hydroxytryptamine Receptor 1F
Gene Information Card
| Symbol | HTR1F |
|---|---|
| Full Name | 5-Hydroxytryptamine Receptor 1F |
| Gene Type | protein-coding |
| Chromosomal Location | 3p12.1 |
| NCBI Gene ID | 3355 ncbi.nlm.nih.gov/gene/3355 |
| Ensembl ID | ENSG00000179094 |
| UniProt ID | P30939 |
| OMIM ID | 182134 |
| HGNC ID | 5299 |
| Aliases | 5-HT1F, 5-HT-1F, HTR1F_HUMAN |
Description
The HTR1F gene encodes the 5-hydroxytryptamine receptor 1F (5-HT1F), a G protein-coupled receptor for serotonin (5-hydroxytryptamine). It is primarily expressed in the central nervous system, particularly in the cortex, hippocampus, and trigeminal ganglia. Activation of 5-HT1F inhibits adenylyl cyclase activity, reducing cAMP levels. This receptor is a target for triptan drugs used in migraine therapy, as it modulates neurotransmitter release and vasoconstriction.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Migraine | Receptor activation by triptans inhibits neuropeptide release and reduces trigeminal nociception | ClinVar, OMIM |
| Cluster Headache | Potential involvement in trigeminal autonomic cephalalgias via serotonergic modulation | OMIM |
| Depression | Altered serotonergic signaling may contribute to mood disorders; indirect evidence from receptor pharmacology | NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 4.2 | Medium |
| Cerebral Cortex | 5.1 | Medium |
| Hippocampus | 3.8 | Low |
| Trigeminal Ganglion | 6.0 | High |
| Testis | 1.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y | 2.5 | Neuroblastoma cell line |
| U-87 MG | 1.8 | Glioblastoma cell line |
| HEK293 | 0.5 | Low endogenous expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Cys) | Missense | <0.01% | Unknown functional impact; rare variant |
| c.457G>A (p.Val153Ile) | Missense | <0.01% | Likely benign; no known disease association |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • serotonin binding |
| • serotonin receptor activity | • adenylate cyclase inhibiting G protein-coupled receptor signaling pathway |
| • chemical synaptic transmission | • nervous system development |
Pathways
• Serotonergic synapse (KEGG: hsa04726)
• GPCR downstream signaling
• cAMP signaling pathway
Protein Summary
The 5-HT1F receptor is a 366-amino acid integral membrane protein with seven transmembrane domains. It couples to Gi/Go proteins, inhibiting adenylyl cyclase and reducing intracellular cAMP. The receptor is involved in serotonergic neurotransmission and is a key target for acute migraine treatment. Its expression in trigeminal ganglia supports a role in pain modulation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| HTR1F Knockout HEK293 Cell Line | EDJ-KQ1786 | Human | 3355 | Details Get a Quote |
| HTR1F Knockout HeLa Cell Line | EDJ-KQ53590 | Human | 3355 | Details Get a Quote |
| HTR1F Knockout A-549 Cell Line | EDJ-KQ62058 | Human | 3355 | Details Get a Quote |
| HTR1F Knockout HCT 116 Cell Line | EDJ-KQ70540 | Human | 3355 | Details Get a Quote |
