HSPA1B (Heat Shock Protein Family A (Hsp70) Member 1B)
A stress-inducible molecular chaperone involved in protein folding, cytoprotection, and immune modulation; implicated in autoimmune and neurodegenerative diseases.
Gene Information Card
| Symbol | HSPA1B |
|---|---|
| Full Name | Heat Shock Protein Family A (Hsp70) Member 1B |
| Gene Type | protein-coding |
| Chromosomal Location | 6p21.33 (GRCh38) |
| NCBI Gene ID | 3304 ncbi.nlm.nih.gov/gene/3304 |
| Ensembl ID | ENSG00000204388 |
| UniProt ID | P0DMV9 |
| OMIM ID | 603012 |
| HGNC ID | 5233 |
| Aliases | HSP70-2, HSP70.2, HSPA1A, HSP70-1B |
Description
HSPA1B encodes a 70 kDa heat shock protein that is strongly induced by cellular stress (e.g., heat, oxidative stress, inflammation). As a molecular chaperone, it assists in protein folding, prevents aggregation of denatured proteins, and facilitates protein transport and degradation. It also plays roles in immune responses and cytoprotection. HSPA1B is part of the highly homologous HSPA1A/HSPA1B pair located in the major histocompatibility complex (MHC) class III region.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Rheumatoid Arthritis | HSPA1B polymorphisms (e.g., +1267 A/G) may influence susceptibility and severity, possibly via altered chaperone function and immune modulation. | Association studies; PMID: 10984555 |
| Type 1 Diabetes | Variants in HSPA1B have been linked to risk, potentially through effects on antigen presentation and autoimmune response. | Genetic association; PMID: 15199473 |
| Alzheimer's Disease | HSPA1B expression is altered in affected brains; chaperone dysfunction may contribute to protein aggregation pathology. | Expression studies; PMID: 16936722 |
| Parkinson's Disease | HSPA1B may modulate alpha-synuclein toxicity; polymorphisms could affect disease risk. | Functional studies; PMID: 20624804 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.3 | Medium |
| Kidney | 10.1 | Medium |
| Heart | 8.5 | Low |
| Brain | 6.2 | Low |
| Testis | 15.7 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 18.4 | High baseline; induced by heat shock |
| A549 | 12.0 | Moderate; inducible |
| MCF7 | 9.8 | Moderate |
| K562 | 7.5 | Low |
| HepG2 | 14.2 | High |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs1061581 (A/G) | SNP | ~40% (G allele) | Associated with altered HSP70 expression and disease susceptibility |
| rs539689 (C/T) | SNP | ~30% (T allele) | May affect promoter activity and stress response |
| rs2227956 (A/G) | SNP | ~20% (G allele) | Coding variant (Met493Thr) with potential functional impact |
Mutation functional classification
Loss of Function (LOF)
Rare loss-of-function mutations are not well documented; complete knockout in mice is viable but shows impaired stress tolerance.
Gain of Function (GOF)
No clear gain-of-function mutations reported; overexpression is generally protective.
Dominant Negative (DN)
No dominant-negative variants described in human disease.
View complete mutation data：
Gene Ontology (GO)
| • ATP binding | • ATP hydrolysis activity |
| • chaperone binding | • protein folding |
| • response to heat | • cellular response to unfolded protein |
| • protein refolding | • ubiquitin-dependent protein catabolic process |
Pathways
• Protein processing in endoplasmic reticulum (KEGG hsa04141)
• Antigen processing and presentation (KEGG hsa04612)
• MAPK signaling pathway (KEGG hsa04010)
• Heat shock response (Reactome R-HSA-3371568)
Protein Summary
HSPA1B is a 70 kDa heat shock protein that functions as an ATP-dependent molecular chaperone. It binds to exposed hydrophobic patches of unfolded or misfolded proteins, promoting proper folding and preventing aggregation. It also participates in the degradation of irreversibly damaged proteins via the ubiquitin-proteasome system. In addition to its chaperone role, HSPA1B modulates immune responses by influencing antigen presentation and cytokine production. Its expression is low under normal conditions but rapidly induced upon stress, making it a key cytoprotective factor.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| HSPA1B Knockout HEK293 Cell Line | EDJ-KQ50367 | Human | 3304 | Details Get a Quote |
| HSPA1B Knockout HeLa Cell Line | EDJ-KQ53580 | Human | 3304 | Details Get a Quote |
| HSPA1B Knockout A-549 Cell Line | EDJ-KQ62047 | Human | 3304 | Details Get a Quote |
| HSPA1B Knockout HCT 116 Cell Line | EDJ-KQ70528 | Human | 3304 | Details Get a Quote |
