HSPA13: Heat Shock Protein Family A (Hsp70) Member 13
A member of the Hsp70 chaperone family involved in protein folding and stress response
Gene Information Card
| Symbol | HSPA13 |
|---|---|
| Full Name | Heat Shock Protein Family A (Hsp70) Member 13 |
| Gene Type | Protein coding |
| Chromosomal Location | 21q11.2 |
| NCBI Gene ID | 6782 ncbi.nlm.nih.gov/gene/6782 |
| Ensembl ID | ENSG00000154760 |
| UniProt ID | P48723 |
| OMIM ID | 601103 |
| HGNC ID | 5237 |
| Aliases | STCH, HSP70-13 |
Description
HSPA13 (Heat Shock Protein Family A (Hsp70) Member 13) is a protein-coding gene located on chromosome 21q11.2. It encodes a member of the Hsp70 family of heat shock proteins, which function as molecular chaperones involved in protein folding, assembly, and transport. HSPA13 is also known as STCH (stress 70 protein chaperone) and is implicated in cellular stress responses and protein homeostasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not established | No direct evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Liver | 6.1 | Low |
| Heart | 5.4 | Low |
| Kidney | 4.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.3 | High expression |
| HeLa | 10.1 | Moderate expression |
| K562 | 7.8 | Low expression |
| HepG2 | 6.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported in ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No known loss-of-function mutations reported.
Gain of Function (GOF)
No known gain-of-function mutations reported.
Dominant Negative (DN)
No known dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • ATP binding (GO:0005524) | • protein folding (GO:0006457) |
| • response to heat (GO:0009408) | • heat shock protein binding (GO:0031072) |
| • unfolded protein binding (GO:0051082) |
Pathways
• Protein processing in endoplasmic reticulum (KEGG: hsa04141)
• Heat shock response (Reactome: R-HSA-3371556)
Protein Summary
HSPA13 encodes a 70 kDa heat shock protein (Hsp70) family member, also known as STCH. The protein functions as a molecular chaperone, binding to unfolded or misfolded proteins to facilitate proper folding and prevent aggregation. It is ATP-dependent and plays a role in cellular stress responses, particularly under heat shock conditions. HSPA13 is localized to the cytoplasm and nucleus.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| HSPA13 Knockout HEK293 Cell Line | EDJ-KQ5857 | Human | 6782 | Details Get a Quote |
| HSPA13 Knockout A-549 Cell Line | EDJ-KQ29328 | Human | 6782 | Details Get a Quote |
| HSPA13 Knockout HCT 116 Cell Line | EDJ-KQ29329 | Human | 6782 | Details Get a Quote |
| HSPA13 Knockout HeLa Cell Line | EDJ-KQ29330 | Human | 6782 | Details Get a Quote |
