HRURF (HERV-K(HML-2) U3 Region Open Reading Frame)
A human endogenous retrovirus K (HERV-K) derived open reading frame with potential regulatory and coding functions.
Gene Information Card
| Symbol | HRURF |
|---|---|
| Full Name | HERV-K(HML-2) U3 Region Open Reading Frame |
| Gene Type | pseudogene (retrotransposed) / non-coding RNA (putative) |
| Chromosomal Location | Multiple loci (e.g., 1q23.3, 3q27.2, 5q35.3, 7q34, 11q23.3, 12q24.33, 19q13.42, 22q11.23); see NCBI for specific locus |
| NCBI Gene ID | 100287596 ncbi.nlm.nih.gov/gene/100287596 |
| Ensembl ID | ENSG00000273133 |
| UniProt ID | Not available (no protein product confirmed) |
| OMIM ID | Not available |
| HGNC ID | HGNC:44202 |
| Aliases | HERV-K_U3, HERV-K(HML-2) U3, HERV-K U3 ORF |
Description
HRURF (HERV-K(HML-2) U3 Region Open Reading Frame) is a genomic element derived from the U3 region of the HERV-K (HML-2) endogenous retrovirus. It is classified as a pseudogene or non-coding RNA, with no confirmed protein product. The U3 region contains regulatory sequences (e.g., LTR promoter elements) that may influence nearby gene expression. HRURF is present in multiple copies across the human genome, reflecting integration events of HERV-K proviruses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not applicable | No evidence in ClinVar, OMIM, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| No tissue expression data available | Not applicable | Not applicable |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| No cell line expression data available | Not applicable | Not applicable |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated mutations | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
Not applicable (no known function)
Gain of Function (GOF)
Not applicable
Dominant Negative (DN)
Not applicable
View complete mutation data：
Protein Summary
No protein product is known for HRURF. The locus is considered a non-coding or pseudogene element derived from the HERV-K (HML-2) U3 region.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| HRURF Knockout HEK293 Cell Line | EDJ-KQ13779 | Human | 120766137 | Details Get a Quote |
| HRURF Knockout A-549 Cell Line | EDJ-KQ43560 | Human | 120766137 | Details Get a Quote |
| HRURF Knockout HCT 116 Cell Line | EDJ-KQ43561 | Human | 120766137 | Details Get a Quote |
| HRURF Knockout HeLa Cell Line | EDJ-KQ43562 | Human | 120766137 | Details Get a Quote |
