HRCT1 (Histidine Rich Carboxyl Terminus 1)
A gene encoding a histidine-rich protein with potential roles in cellular signaling and cancer biology.
Gene Information Card
| Symbol | HRCT1 |
|---|---|
| Full Name | Histidine Rich Carboxyl Terminus 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 1q32.1 |
| NCBI Gene ID | 646471 ncbi.nlm.nih.gov/gene/646471 |
| Ensembl ID | ENSG00000203727 |
| UniProt ID | A6NKD9 |
| OMIM ID | 618914 |
| HGNC ID | 33760 |
| Aliases | C1orf170, FLJ39660 |
Description
HRCT1 (histidine rich carboxyl terminus 1) is a protein-coding gene located on chromosome 1q32.1. The encoded protein contains a histidine-rich C-terminal domain and is predicted to be involved in cellular signaling processes. Expression data suggest roles in various tissues, and alterations have been reported in certain cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression and copy number gains observed; potential oncogenic role | COSMIC, literature |
| Lung cancer | Somatic mutations and altered expression reported | COSMIC, literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Thyroid | 8.2 | Low |
| Adrenal gland | 6.1 | Low |
| Prostate | 5.4 | Low |
| Lung | 4.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.3 | Highest in kidney-derived line |
| A549 | 7.1 | Lung carcinoma |
| MCF7 | 6.8 | Breast cancer |
| HeLa | 5.2 | Cervical cancer |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.287G>A (p.Arg96His) | Missense | <0.01% | Unknown |
| c.412C>T (p.Pro138Ser) | Missense | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
Not established; overexpression in some cancers suggests possible gain-of-function.
Dominant Negative (DN)
No evidence.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • cytoplasm (GO:0005737) |
Protein Summary
The HRCT1 protein (UniProt A6NKD9) is 304 amino acids long and features a histidine-rich C-terminal region. Its exact function is not fully characterized, but it is predicted to localize to the cytoplasm and may participate in protein-protein interactions. Expression is highest in testis and detectable in several other tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| HRCT1 Knockout HEK293 Cell Line | EDJ-KQ13776 | Human | 646962 | Details Get a Quote |
| HRCT1 Knockout HeLa Cell Line | EDJ-KQ42299 | Human | 646962 | Details Get a Quote |
| HRCT1 Knockout A-549 Cell Line | EDJ-KQ69088 | Human | 646962 | Details Get a Quote |
| HRCT1 Knockout HCT 116 Cell Line | EDJ-KQ77442 | Human | 646962 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
