HOMER3
Homer scaffold protein 3
Gene Information Card
| Symbol | HOMER3 |
|---|---|
| Full Name | homer scaffold protein 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 19p13.11 |
| NCBI Gene ID | 9454 ncbi.nlm.nih.gov/gene/9454 |
| Ensembl ID | ENSG00000105329 |
| UniProt ID | Q9NSC5 |
| OMIM ID | 604800 |
| HGNC ID | 17521 |
| Aliases | HOMER-3, VESL-3, HOMER3a, HOMER3b |
Description
HOMER3 encodes a member of the Homer family of scaffold proteins that regulate metabotropic glutamate receptor signaling and intracellular calcium dynamics. The protein contains an N-terminal Ena/VASP homology 1 (EVH1) domain that binds proline-rich motifs and a C-terminal coiled-coil domain mediating oligomerization. HOMER3 is involved in synaptic plasticity, immune cell activation, and cancer cell migration.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | HOMER3 overexpression promotes cell proliferation and migration via PI3K/Akt pathway | PMID: 31827273 |
| Gastric cancer | Upregulation of HOMER3 correlates with poor prognosis and increased invasion | PMID: 31065072 |
| Colorectal cancer | HOMER3 silencing reduces tumor growth and metastasis in vitro | PMID: 29393410 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.3 | Medium |
| Liver | 8.7 | Low |
| Kidney | 6.5 | Low |
| Lung | 5.2 | Low |
| Spleen | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.6 | Hepatocellular carcinoma cell line |
| MCF7 | 9.2 | Breast cancer cell line |
| A549 | 7.8 | Lung adenocarcinoma cell line |
| HEK293 | 6.4 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.344C>T (p.Pro115Leu) | Missense | <0.01% | Unknown functional effect |
| c.487G>A (p.Gly163Arg) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in HOMER3.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in HOMER3.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported in HOMER3.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • PDZ domain binding (GO:0030165) |
| • synapse (GO:0045202) | • chemical synaptic transmission (GO:0007268) |
| • plasma membrane (GO:0005886) |
Pathways
• Metabotropic glutamate receptor signaling (Reactome: R-HSA-418594)
• PI3K/Akt signaling (KEGG: hsa04151)
Protein Summary
HOMER3 is a 361-amino acid scaffold protein (UniProt Q9NSC5) that forms homo- and hetero-oligomers with other Homer proteins. It links metabotropic glutamate receptors to intracellular calcium stores and modulates signaling complexes in neurons and immune cells. The protein is expressed in multiple tissues and is implicated in cancer progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| HOMER3 Knockout HEK293 Cell Line | EDJ-KQ1529 | Human | 9454 | Details Get a Quote |
| HOMER3 Knockout A-549 Cell Line | EDJ-KQ21176 | Human | 9454 | Details Get a Quote |
| HOMER3 Knockout HCT 116 Cell Line | EDJ-KQ21177 | Human | 9454 | Details Get a Quote |
| HOMER3 Knockout HeLa Cell Line | EDJ-KQ21178 | Human | 9454 | Details Get a Quote |
