HNRNPUL2 Gene - Heterogeneous Nuclear Ribonucleoprotein U Like 2
Comprehensive genomic and functional annotation of HNRNPUL2
Gene Information Card
| Symbol | HNRNPUL2 |
|---|---|
| Full Name | heterogeneous nuclear ribonucleoprotein U like 2 |
| Gene Type | protein coding |
| Chromosomal Location | 11q12.3 |
| NCBI Gene ID | 221092 ncbi.nlm.nih.gov/gene/221092 |
| Ensembl ID | ENSG00000149257 |
| UniProt ID | Q1KMD3 |
| OMIM ID | 618502 |
| HGNC ID | 25139 |
| Aliases | HNRPUL2, HNRPU-like 2, FLJ10656 |
Description
HNRNPUL2 encodes a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. The protein contains an RNA recognition motif and is involved in pre-mRNA processing, RNA transport, and chromatin remodeling. It binds to scaffold attachment factor A (SAF-A) and may play a role in transcriptional regulation and DNA damage response.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered expression and splicing regulation; HNRNPUL2 may influence tumor progression through RNA processing | PMID: 25691885 |
| Colorectal cancer | Upregulation associated with poor prognosis; potential role in cell proliferation | PMID: 30348671 |
| Lung cancer | Differential expression in non-small cell lung cancer; involvement in RNA metabolism | PMID: 29029998 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Lymph node | 12.8 | Medium |
| Bone marrow | 11.5 | Medium |
| Spleen | 10.9 | Medium |
| Brain | 8.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 14.5 | Cervical adenocarcinoma |
| K562 | 13.2 | Leukemia |
| HepG2 | 12.1 | Hepatocellular carcinoma |
| A549 | 11.8 | Lung carcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234G>A (p.Glu412Lys) | Missense | 0.02% (gnomAD) | Unknown functional effect |
| c.567_568insC (p.Leu190fs) | Frameshift | <0.01% | Predicted loss of function |
| c.890T>C (p.Ile297Thr) | Missense | 0.01% | Possibly damaging (PolyPhen-2) |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense variants predicted to cause nonsense-mediated decay or truncated protein.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
Not described in literature.
View complete mutation data：
Gene Ontology (GO)
| • RNA binding (GO:0003723) | • nucleic acid binding (GO:0003676) |
| • nucleus (GO:0005634) | • nucleoplasm (GO:0005654) |
| • mRNA processing (GO:0006397) | • RNA splicing (GO:0008380) |
Pathways
• Processing of Capped Intron-Containing Pre-mRNA (Reactome: R-HSA-72203)
• mRNA Splicing - Major Pathway (Reactome: R-HSA-72163)
• Gene Expression (Reactome: R-HSA-74160)
Protein Summary
HNRNPUL2 is a 747-amino acid protein with a molecular weight of approximately 85 kDa. It contains an N-terminal SAP domain and a C-terminal RRM domain. The protein localizes to the nucleus and is involved in pre-mRNA splicing, RNA export, and chromatin organization. It interacts with scaffold attachment factor A (SAF-A) and may modulate transcription.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| HNRNPUL2 Knockout HEK293 Cell Line | EDJ-KQ8798 | Human | 221092 | Details Get a Quote |
| HNRNPUL2 Knockout A-549 Cell Line | EDJ-KQ35088 | Human | 221092 | Details Get a Quote |
| HNRNPUL2 Knockout HCT 116 Cell Line | EDJ-KQ35089 | Human | 221092 | Details Get a Quote |
| HNRNPUL2 Knockout HeLa Cell Line | EDJ-KQ33838 | Human | 221092 | Details Get a Quote |
