HNRNPCL4 Gene: Heterogeneous Nuclear Ribonucleoprotein C-Like 4
A primate-specific gene encoding a putative RNA-binding protein with limited functional characterization.
Gene Information Card
| Symbol | HNRNPCL4 |
|---|---|
| Full Name | heterogeneous nuclear ribonucleoprotein C like 4 |
| Gene Type | protein coding |
| Chromosomal Location | 1p36.21 |
| NCBI Gene ID | 100287596 ncbi.nlm.nih.gov/gene/100287596 |
| Ensembl ID | ENSG00000240038 |
| UniProt ID | Q5T6M9 |
| OMIM ID | Not available |
| HGNC ID | HGNC:37279 |
| Aliases | HNRPCL4, hnRNP C-like 4 |
Description
HNRNPCL4 is a protein-coding gene located on chromosome 1p36.21. It belongs to the heterogeneous nuclear ribonucleoprotein (hnRNP) C family, which includes genes encoding RNA-binding proteins involved in pre-mRNA processing, mRNA metabolism, and transport. However, HNRNPCL4 is a primate-specific paralog with limited functional characterization. It is predicted to encode a protein containing RNA recognition motifs, but its exact biological role remains largely unknown. The gene is part of a cluster of HNRNPC-like genes on chromosome 1, which arose through retrotransposition and subsequent duplication events.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease association | No known mechanism | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | Not available | Low expression (based on RNA-seq data from GTEx, not available in Human Protein Atlas) |
| Brain | Not available | Low expression |
| Other tissues | Not available | Very low or no expression |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | Not available | Not specifically reported |
| HEK293 | Not available | Not specifically reported |
| K562 | Not available | Not specifically reported |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No clinically significant variants | Not applicable | Not applicable | No known effect |
Mutation functional classification
Loss of Function (LOF)
No loss-of-function mutations have been reported in ClinVar or COSMIC.
Gain of Function (GOF)
No gain-of-function mutations have been reported.
Dominant Negative (DN)
No dominant-negative mutations have been reported.
View complete mutation data：
Gene Ontology (GO)
| • RNA binding (predicted) | • nucleotide binding (predicted) |
| • mRNA processing (predicted) |
Pathways
• No specific pathways are curated for HNRNPCL4 in Reactome or KEGG.
Protein Summary
The HNRNPCL4 protein is predicted to be 298 amino acids long and contains an RNA recognition motif (RRM) domain, similar to other hnRNP C proteins. However, its exact molecular function is not experimentally validated. It may bind RNA and participate in RNA metabolism, but due to its low expression and lack of functional studies, its physiological relevance is unclear. The protein is likely localized to the nucleus, as are other hnRNP C family members.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| HNRNPCL4 Knockout HEK293 Cell Line | EDJ-KQ13769 | Human | 101060301 | Details Get a Quote |
| HNRNPCL4 Knockout HeLa Cell Line | EDJ-KQ60992 | Human | 101060301 | Details Get a Quote |
| HNRNPCL4 Knockout A-549 Cell Line | EDJ-KQ69466 | Human | 101060301 | Details Get a Quote |
| HNRNPCL4 Knockout HCT 116 Cell Line | EDJ-KQ77819 | Human | 101060301 | Details Get a Quote |
