HNRNPCL3 Gene - Heterogeneous Nuclear Ribonucleoprotein C Like 3
A primate-specific gene encoding a protein similar to hnRNP C, potentially involved in RNA processing and tumor immunity.
Gene Information Card
| Symbol | HNRNPCL3 |
|---|---|
| Full Name | heterogeneous nuclear ribonucleoprotein C like 3 |
| Gene Type | protein coding |
| Chromosomal Location | 4p15.31 |
| NCBI Gene ID | 343453 ncbi.nlm.nih.gov/gene/343453 |
| Ensembl ID | ENSG00000283036 |
| UniProt ID | Q5T6M6 |
| OMIM ID | Not available |
| HGNC ID | HGNC:37290 |
| Aliases | HNRPCL3, hnRNP C-like 3 |
Description
HNRNPCL3 is a protein-coding gene located on chromosome 4p15.31. It belongs to the heterogeneous nuclear ribonucleoprotein (hnRNP) family, specifically similar to hnRNP C. The gene is primate-specific and encodes a protein that may be involved in RNA binding and processing. Expression is enriched in testis and certain cancer cell lines, suggesting roles in germ cell biology and tumor immunity.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (pan-cancer) | HNRNPCL3 expression is elevated in multiple tumor types and may act as a cancer/testis antigen, eliciting immune responses. | Expression data from TCGA and GTEx; immunogenicity inferred from peptide presentation studies. |
| Testicular germ cell tumors | High expression in normal testis and some germ cell tumors; potential role in spermatogenesis or tumor progression. | Expression profiling studies (e.g., GTEx, CCLE). |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.7 | Medium |
| Bone marrow | 2.1 | Low |
| Lymph node | 1.5 | Low |
| Other tissues | <1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K562 | 15.3 | Leukemia cell line; high expression |
| HPAF-II | 8.2 | Pancreatic cancer cell line; moderate expression |
| A549 | 3.4 | Lung cancer cell line; low expression |
| MCF7 | 1.2 | Breast cancer cell line; low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1Val) | Missense | Rare (0.01%) | Potential loss of start codon; effect unknown |
| c.215C>T (p.Pro72Leu) | Missense | Rare (0.02%) | May affect protein stability; no clinical significance reported |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported; gene is not essential in somatic cells.
Gain of Function (GOF)
No evidence of gain-of-function mutations; overexpression in tumors may be due to epigenetic activation.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • RNA binding (GO:0003723) | • nucleic acid binding (GO:0003676) |
| • nuclear speck (GO:0016607) |
Pathways
• RNA processing (Reactome: R-HSA-8953854)
• Metabolism of RNA (Reactome: R-HSA-8953854)
Protein Summary
The HNRNPCL3 protein is 314 amino acids long and shares high similarity with hnRNP C1/C2. It contains an RNA recognition motif (RRM) and a C-terminal acidic domain. It is predicted to localize to the nucleus and may participate in pre-mRNA processing. Its expression is largely restricted to testis and cancer cells, suggesting a role as a cancer/testis antigen.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| HNRNPCL3 Knockout HEK293 Cell Line | EDJ-KQ13768 | Human | 649330 | Details Get a Quote |
| HNRNPCL3 Knockout HeLa Cell Line | EDJ-KQ60628 | Human | 649330 | Details Get a Quote |
| HNRNPCL3 Knockout A-549 Cell Line | EDJ-KQ69099 | Human | 649330 | Details Get a Quote |
| HNRNPCL3 Knockout HCT 116 Cell Line | EDJ-KQ77452 | Human | 649330 | Details Get a Quote |
