HNRNPCL2 Gene - Heterogeneous Nuclear Ribonucleoprotein C Like 2
Complete gene guide for HNRNPCL2: location, function, expression, and clinical significance.
Gene Information Card
| Symbol | HNRNPCL2 |
|---|---|
| Full Name | heterogeneous nuclear ribonucleoprotein C like 2 |
| Gene Type | gene with protein product |
| Chromosomal Location | 1p36.21 |
| NCBI Gene ID | 440563 ncbi.nlm.nih.gov/gene/440563 |
| Ensembl ID | ENSG00000275774 |
| UniProt ID | B2RXH8 |
| OMIM ID | Not available |
| HGNC ID | HGNC:48813 |
| Aliases | HNRNPCP5 |
Description
HNRNPCL2 (heterogeneous nuclear ribonucleoprotein C like 2) is a gene located on chromosome 1p36.21. It encodes a protein that shares similarity with heterogeneous nuclear ribonucleoprotein C (HNRNPC), which is involved in pre-mRNA processing. The gene is considered a member of the HNRNPC-like family, though its specific functions are not fully characterized. It is expressed in various tissues, with notable expression in the testis and certain brain regions. The protein is predicted to localize to the nucleus and may participate in RNA binding and processing. Further research is needed to elucidate its precise biological roles and potential implications in disease.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Not established | No direct disease association has been reported for HNRNPCL2. | No evidence from ClinVar or OMIM. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Brain | 8.7 | Low |
| Lung | 5.2 | Low |
| Kidney | 4.1 | Low |
| Liver | 3.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.2 | High expression |
| K562 | 8.9 | Moderate expression |
| A549 | 6.3 | Low expression |
| MCF7 | 4.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No known pathogenic variants | Not applicable | Not reported | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No loss-of-function mutations have been characterized for HNRNPCL2.
Gain of Function (GOF)
No gain-of-function mutations have been characterized for HNRNPCL2.
Dominant Negative (DN)
No dominant-negative mutations have been characterized for HNRNPCL2.
View complete mutation data：
Gene Ontology (GO)
| • RNA binding | • nucleic acid binding |
| • nucleus | • ribonucleoprotein complex |
Pathways
• mRNA processing
• RNA splicing
Protein Summary
The HNRNPCL2 protein is predicted to be a heterogeneous nuclear ribonucleoprotein C-like protein. It contains RNA recognition motifs and is likely involved in RNA binding and processing. The protein is localized to the nucleus and may participate in pre-mRNA splicing and other aspects of RNA metabolism. Its exact function remains to be determined, but it may play a role in gene expression regulation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| HNRNPCL2 Knockout HEK293 Cell Line | EDJ-KQ13767 | Human | 440563 | Details Get a Quote |
| HNRNPCL2 Knockout HeLa Cell Line | EDJ-KQ60396 | Human | 440563 | Details Get a Quote |
| HNRNPCL2 Knockout A-549 Cell Line | EDJ-KQ68864 | Human | 440563 | Details Get a Quote |
| HNRNPCL2 Knockout HCT 116 Cell Line | EDJ-KQ77226 | Human | 440563 | Details Get a Quote |
