HNRNPCL1 Gene
Heterogeneous Nuclear Ribonucleoprotein C Like 1
Gene Information Card
| Symbol | HNRNPCL1 |
|---|---|
| Full Name | Heterogeneous Nuclear Ribonucleoprotein C Like 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 1p36.21 |
| NCBI Gene ID | 343069 ncbi.nlm.nih.gov/gene/343069 |
| Ensembl ID | ENSG00000204310 |
| UniProt ID | Q9BZJ0 |
| OMIM ID | 617391 |
| HGNC ID | 24835 |
| Aliases | HNRPCL1, HNRPC-like 1, HNRNPC-like 1 |
Description
HNRNPCL1 is a protein-coding gene that belongs to the heterogeneous nuclear ribonucleoprotein (hnRNP) family. It encodes a protein similar to hnRNP C, involved in pre-mRNA processing, RNA splicing, and transport. The gene is located on chromosome 1p36.21 and is expressed in multiple tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | Not applicable | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Brain | 8.5 | Low |
| Lung | 6.1 | Low |
| Liver | 4.3 | Low |
| Kidney | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 12.0 | Moderate expression |
| HeLa | 9.5 | Low expression |
| K562 | 7.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • RNA binding | • nucleic acid binding |
| • mRNA processing | • spliceosomal complex |
Pathways
• mRNA Splicing - Major Pathway
Protein Summary
The HNRNPCL1 protein is a member of the hnRNP family, characterized by RNA recognition motifs. It is predicted to be involved in RNA metabolism, including splicing and transport. The protein is localized to the nucleus and shares structural similarity with HNRNPC.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| HNRNPCL1 Knockout HEK293 Cell Line | EDJ-KQ13766 | Human | 343069 | Details Get a Quote |
| HNRNPCL1 Knockout HeLa Cell Line | EDJ-KQ59745 | Human | 343069 | Details Get a Quote |
| HNRNPCL1 Knockout A-549 Cell Line | EDJ-KQ68214 | Human | 343069 | Details Get a Quote |
| HNRNPCL1 Knockout HCT 116 Cell Line | EDJ-KQ76590 | Human | 343069 | Details Get a Quote |
