HNRNPA0
Heterogeneous Nuclear Ribonucleoprotein A0
Gene Information Card
| Symbol | HNRNPA0 |
|---|---|
| Full Name | Heterogeneous Nuclear Ribonucleoprotein A0 |
| Gene Type | Protein coding |
| Chromosomal Location | 5q31.2 |
| NCBI Gene ID | 10949 ncbi.nlm.nih.gov/gene/10949 |
| Ensembl ID | ENSG00000177733 |
| UniProt ID | Q13151 |
| OMIM ID | 609409 |
| HGNC ID | 5030 |
| Aliases | hnRNP A0, HNRPA0 |
Description
HNRNPA0 encodes a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. The protein is involved in pre-mRNA processing, including splicing, polyadenylation, and transport. It binds to RNA and DNA, and plays a role in the regulation of gene expression at the post-transcriptional level.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in ClinVar or OMIM | Not applicable | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Lymph node | 12.8 | Medium |
| Spleen | 11.5 | Medium |
| Bone marrow | 10.9 | Medium |
| Brain | 8.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 | 14.1 | Leukemia cell line |
| HeLa | 12.5 | Cervical carcinoma |
| HepG2 | 11.0 | Hepatocellular carcinoma |
| A549 | 10.2 | Lung carcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No recurrent mutations reported in COSMIC | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data
Gain of Function (GOF)
No data
Dominant Negative (DN)
No data
View complete mutation data：
Gene Ontology (GO)
| • RNA binding | • nucleic acid binding |
| • mRNA processing | • spliceosomal complex |
| • nucleus |
Pathways
• mRNA Splicing - Major Pathway
• Processing of Capped Intron-Containing Pre-mRNA
Protein Summary
HNRNPA0 is a 305-amino acid RNA-binding protein with two RNA recognition motifs (RRMs). It shuttles between the nucleus and cytoplasm and is involved in mRNA metabolism. The protein is ubiquitously expressed with higher levels in testis and lymphoid tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| HNRNPA0 Knockout HEK293 Cell Line | EDJ-KQ2241 | Human | 10949 | Details Get a Quote |
| HNRNPA0 Knockout A-549 Cell Line | EDJ-KQ23906 | Human | 10949 | Details Get a Quote |
| HNRNPA0 Knockout HCT 116 Cell Line | EDJ-KQ23908 | Human | 10949 | Details Get a Quote |
| HNRNPA0 Knockout HeLa Cell Line | EDJ-KQ23909 | Human | 10949 | Details Get a Quote |
