HMGN4 Gene - High Mobility Group Nucleosomal Binding Domain 4
A member of the HMGN protein family involved in chromatin structure regulation and transcriptional modulation.
Gene Information Card
| Symbol | HMGN4 |
|---|---|
| Full Name | High Mobility Group Nucleosomal Binding Domain 4 |
| Gene Type | Protein coding |
| Chromosomal Location | 6p21.31 |
| NCBI Gene ID | 10473 ncbi.nlm.nih.gov/gene/10473 |
| Ensembl ID | ENSG00000112210 |
| UniProt ID | O00479 |
| OMIM ID | 603900 |
| HGNC ID | 4986 |
| Aliases | NBP-45, HMG17L3, NBP45 |
Description
HMGN4 encodes a member of the high mobility group N (HMGN) family of nucleosomal binding proteins. These proteins bind to nucleosomes and modulate chromatin structure, thereby influencing transcription, replication, and DNA repair. HMGN4 is specifically expressed in certain tissues and may play a role in cellular differentiation and development.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No direct evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.2 | Medium |
| Bone marrow | 8.9 | Medium |
| Thymus | 7.6 | Low |
| Lung | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 | 15.3 | Leukemia cell line |
| HeLa | 8.7 | Cervical carcinoma |
| HepG2 | 6.1 | Hepatocellular carcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No known loss-of-function mutations reported.
Gain of Function (GOF)
No known gain-of-function mutations reported.
Dominant Negative (DN)
No known dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • nucleosome (GO:0000786) | • nucleus (GO:0005634) |
| • DNA binding (GO:0003677) | • histone binding (GO:0042393) |
| • nucleosome assembly (GO:0006334) |
Protein Summary
HMGN4 is a 90-amino acid protein that belongs to the HMGN family. It contains a nucleosomal binding domain that allows it to interact with nucleosomes, reducing the compaction of chromatin and facilitating access for transcription factors. The protein is predominantly nuclear and is expressed in hematopoietic tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| HMGN4 Knockout HEK293 Cell Line | EDJ-KQ3640 | Human | 10473 | Details Get a Quote |
| HMGN4 Knockout A-549 Cell Line | EDJ-KQ25593 | Human | 10473 | Details Get a Quote |
| HMGN4 Knockout HCT 116 Cell Line | EDJ-KQ25594 | Human | 10473 | Details Get a Quote |
| HMGN4 Knockout HeLa Cell Line | EDJ-KQ25595 | Human | 10473 | Details Get a Quote |
