HDGF (Heparin Binding Growth Factor) Gene
A comprehensive overview of the HDGF gene, including its genomic context, expression, and role in disease.
Gene Information Card
| Symbol | HDGF |
|---|---|
| Full Name | Heparin Binding Growth Factor |
| Gene Type | Protein coding |
| Chromosomal Location | 1q23.1 |
| NCBI Gene ID | 3068 ncbi.nlm.nih.gov/gene/3068 |
| Ensembl ID | ENSG00000143321 |
| UniProt ID | P51858 |
| OMIM ID | 600387 |
| HGNC ID | 4856 |
| Aliases | HMG1L2, HMG-1L2, HMG1L2A, HMG1L2B |
Description
HDGF (heparin binding growth factor) is a protein-coding gene located on chromosome 1q23.1. It encodes a growth factor that binds heparin and is involved in cell proliferation, differentiation, and angiogenesis. The protein contains a DNA-binding domain and is implicated in various cancers and developmental processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | Overexpression of HDGF promotes tumor growth and angiogenesis via MAPK/ERK signaling | PMID: 15604214 |
| Non-small cell lung cancer | HDGF upregulation correlates with poor prognosis and increased metastasis | PMID: 19137029 |
| Gastric cancer | HDGF enhances cell proliferation and invasion through PI3K/Akt pathway | PMID: 21573172 |
| Pancreatic cancer | HDGF expression is associated with tumor progression and chemoresistance | PMID: 22430205 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Lung | 8.3 | Medium |
| Kidney | 6.7 | Low |
| Heart | 4.2 | Low |
| Brain | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.0 | Hepatocellular carcinoma cell line |
| A549 | 10.2 | Lung adenocarcinoma cell line |
| MCF7 | 7.8 | Breast cancer cell line |
| HeLa | 5.5 | Cervical cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.1% | p.Met1Val; potential loss of start codon |
| c.200C>T | Missense | <0.1% | p.Thr67Ile; unknown significance |
| c.350G>A | Missense | <0.1% | p.Arg117His; reported in COSMIC |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
Overexpression and amplification are common in cancers, suggesting gain-of-function effects.
Dominant Negative (DN)
No dominant-negative mutations documented.
View complete mutation data：
Gene Ontology (GO)
| • growth factor activity (GO:0008083) | • protein binding (GO:0005515) |
| • nucleus (GO:0005634) | • positive regulation of cell proliferation (GO:0008284) |
| • angiogenesis (GO:0001525) |
Pathways
• MAPK signaling pathway (Reactome: R-HSA-5673001)
• PI3K-Akt signaling pathway (KEGG: hsa04151)
Protein Summary
The HDGF protein (UniProt P51858) is a 240-amino acid heparin-binding growth factor localized to the nucleus. It contains a DNA-binding domain and is involved in transcriptional regulation, cell proliferation, and angiogenesis. The protein is overexpressed in multiple cancers and is considered a potential therapeutic target.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| HDGFL2 Knockout HEK293 Cell Line | EDJ-KQ10178 | Human | 84717 | Details Get a Quote |
| HDGFL3 Knockout HEK293 Cell Line | EDJ-KQ10814 | Human | 50810 | Details Get a Quote |
| HDGFL1 Knockout HEK293 Cell Line | EDJ-KQ11549 | Human | 154150 | Details Get a Quote |
| HDGF Knockout HEK293 Cell Line | EDJ-KQ13731 | Human | 3068 | Details Get a Quote |
| HDGFL3 Knockout A-549 Cell Line | EDJ-KQ37173 | Human | 50810 | Details Get a Quote |
| HDGFL2 Knockout A-549 Cell Line | EDJ-KQ37296 | Human | 84717 | Details Get a Quote |
| HDGFL2 Knockout HCT 116 Cell Line | EDJ-KQ37297 | Human | 84717 | Details Get a Quote |
| HDGFL2 Knockout HeLa Cell Line | EDJ-KQ37298 | Human | 84717 | Details Get a Quote |
| HDGFL3 Knockout HeLa Cell Line | EDJ-KQ38466 | Human | 50810 | Details Get a Quote |
| HDGF Knockout A-549 Cell Line | EDJ-KQ43492 | Human | 3068 | Details Get a Quote |
| HDGF Knockout HCT 116 Cell Line | EDJ-KQ43493 | Human | 3068 | Details Get a Quote |
| HDGF Knockout HeLa Cell Line | EDJ-KQ43494 | Human | 3068 | Details Get a Quote |
| HDGF Knockout HT-29 Cell Line | EDJ-KZ28 | Human | 3068 | Details Get a Quote |
| HDGF Knockout RD-ES Cell Line | EDJ-KZ280 | Human | 3068 | Details Get a Quote |
| HDGFL1 Knockout HeLa Cell Line | EDJ-KQ58736 | Human | 154150 | Details Get a Quote |
