HCFC2: Host Cell Factor C2
A transcriptional co-regulator involved in cell cycle control and chromatin modification
Gene Information Card
| Symbol | HCFC2 |
|---|---|
| Full Name | Host Cell Factor C2 |
| Gene Type | Protein coding |
| Chromosomal Location | 12q23.3 |
| NCBI Gene ID | 26960 ncbi.nlm.nih.gov/gene/26960 |
| Ensembl ID | ENSG00000111247 |
| UniProt ID | Q9Y4Z0 |
| OMIM ID | 609346 |
| HGNC ID | 4838 |
| Aliases | HCF-2, C2orf15, MGC138290 |
Description
HCFC2 (Host Cell Factor C2) encodes a protein that functions as a transcriptional co-regulator. It is a component of the host cell factor complex, which is involved in cell cycle progression, chromatin modification, and transcriptional regulation. HCFC2 interacts with VP16 and other transcription factors to modulate gene expression. The gene is ubiquitously expressed and plays a role in development and cellular homeostasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in OMIM or ClinVar | Not established | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Brain | 8.7 | Low |
| Liver | 6.3 | Low |
| Heart | 5.1 | Low |
| Kidney | 4.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 12.5 | Embryonic kidney cells |
| HeLa | 9.8 | Cervical carcinoma cells |
| K562 | 7.3 | Leukemia cells |
| HepG2 | 6.1 | Hepatocellular carcinoma cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported in ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No documented loss-of-function mutations in human disease.
Gain of Function (GOF)
No documented gain-of-function mutations.
Dominant Negative (DN)
No documented dominant-negative mutations.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Host cell factor complex pathway
• Transcriptional regulation by VP16
Protein Summary
HCFC2 is a 761-amino acid protein that contains a fibronectin type III domain and a basic leucine zipper (bZIP) domain. It localizes to the nucleus and forms a complex with HCFC1 and other proteins to regulate transcription. The protein is involved in cell cycle control, particularly at the G1/S transition, and in chromatin modification through interaction with histone deacetylases and methyltransferases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| HCFC2 Knockout HEK293 Cell Line | EDJ-KQ9080 | Human | 29915 | Details Get a Quote |
| HCFC2 Knockout HCT 116 Cell Line | EDJ-KQ34316 | Human | 29915 | Details Get a Quote |
| HCFC2 Knockout A-549 Cell Line | EDJ-KQ35567 | Human | 29915 | Details Get a Quote |
| HCFC2 Knockout HeLa Cell Line | EDJ-KQ35569 | Human | 29915 | Details Get a Quote |
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