HAUS2: A Subunit of the HAUS Augmin Complex
Essential for mitotic spindle assembly and centrosome integrity
Gene Information Card
| Symbol | HAUS2 |
|---|---|
| Full Name | HAUS Augmin Like Complex Subunit 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 15q14 |
| NCBI Gene ID | 55182 ncbi.nlm.nih.gov/gene/55182 |
| Ensembl ID | ENSG00000137807 |
| UniProt ID | Q9NVX0 |
| OMIM ID | 613433 |
| HGNC ID | 25183 |
| Aliases | C14orf94, FLJ12716, HCA66 |
Description
HAUS2 encodes a subunit of the HAUS augmin-like complex, which is critical for centrosome-dependent microtubule nucleation and mitotic spindle assembly. The complex recruits γ-tubulin ring complexes to spindle microtubules, ensuring proper chromosome segregation during cell division. HAUS2 is also implicated in centrosome integrity and cell cycle progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression of HAUS2 may promote centrosome amplification and aneuploidy | PMID: 25609812 |
| Colorectal cancer | HAUS2 upregulation correlates with poor prognosis and increased proliferation | PMID: 30348673 |
| Glioblastoma | HAUS2 knockdown reduces tumor cell viability and spindle defects | PMID: 28431213 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Bone marrow | 12.8 | Medium |
| Lymph node | 10.5 | Medium |
| Brain | 6.3 | Low |
| Liver | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 18.5 | High expression; essential for mitotic progression |
| HEK293 | 14.2 | Moderate expression |
| MCF7 | 12.0 | Moderate expression; breast cancer line |
| U2OS | 16.1 | High expression; osteosarcoma line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.287A>G (p.Asn96Ser) | Missense | <0.01% | Unknown; rare variant in population databases |
| c.421C>T (p.Arg141Trp) | Missense | <0.01% | Predicted damaging by SIFT; functional impact unclear |
| c.544_545insA (p.Thr182Asnfs*3) | Frameshift | <0.01% | Loss of function; likely pathogenic in cancer |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations are predicted to cause loss of HAUS2 function, impairing augmin complex assembly and mitotic spindle formation.
Gain of Function (GOF)
No documented gain-of-function mutations in HAUS2.
Dominant Negative (DN)
Missense mutations in the coiled-coil domain may disrupt augmin complex interactions, potentially acting in a dominant-negative manner.
View complete mutation data：
Gene Ontology (GO)
Pathways
• REACT: R-HSA-2500257 - Resolution of Sister Chromatid Cohesion
• REACT: R-HSA-141444 - Amplification of signal from the kinetochores
• REACT: R-HSA-68877 - Mitotic Prometaphase
• REACT: R-HSA-2574192 - Recruitment of NuMA to mitotic centrosomes
Protein Summary
HAUS2 is a 222-amino-acid protein (25.5 kDa) that localizes to centrosomes and spindle microtubules. It contains a coiled-coil domain essential for interaction with other augmin complex subunits. The protein is highly conserved in eukaryotes and is required for proper mitotic spindle assembly and centrosome maturation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| HAUS2 Knockout HEK293 Cell Line | EDJ-KQ13726 | Human | 55142 | Details Get a Quote |
| HAUS2 Knockout A-549 Cell Line | EDJ-KQ43477 | Human | 55142 | Details Get a Quote |
| HAUS2 Knockout HCT 116 Cell Line | EDJ-KQ43478 | Human | 55142 | Details Get a Quote |
| HAUS2 Knockout HeLa Cell Line | EDJ-KQ43479 | Human | 55142 | Details Get a Quote |
