H4C16
H4 clustered histone 16
Gene Information Card
| Symbol | H4C16 |
|---|---|
| Full Name | H4 clustered histone 16 |
| Gene Type | protein-coding |
| Chromosomal Location | 6p22.1 |
| NCBI Gene ID | 8362 ncbi.nlm.nih.gov/gene/8362 |
| Ensembl ID | ENSG00000277775 |
| UniProt ID | P62805 |
| OMIM ID | 602833 |
| HGNC ID | 4795 |
| Aliases | H4/b, H4FB, HIST1H4B, H4C1, H4C2, H4C3, H4C4, H4C5, H4C6, H4C7, H4C8, H4C9, H4C11, H4C12, H4C13, H4C14, H4C15 |
Description
H4C16 is a member of the histone H4 family, which encodes a core histone protein essential for nucleosome assembly. Histone H4, along with H2A, H2B, and H3, forms the octamer core of nucleosomes, the fundamental unit of chromatin. This gene is part of a histone cluster on chromosome 6p22.1 and is replication-dependent, expressed during S phase. The protein is involved in DNA packaging, gene regulation, and epigenetic modifications.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Altered histone H4 expression and post-translational modifications contribute to chromatin dysregulation and oncogenesis. | COSMIC, ClinVar |
| Immunodeficiency | Mutations in histone H4 genes can affect immune cell development and function. | OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone marrow | 12.5 | Medium |
| Lymph node | 10.2 | Medium |
| Spleen | 9.8 | Medium |
| Testis | 8.5 | Medium |
| Brain | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K562 | 15.0 | Leukemia cell line |
| HeLa | 12.3 | Cervical cancer cell line |
| HEK293 | 11.1 | Embryonic kidney cell line |
| HepG2 | 9.5 | Liver cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.1% | Unknown functional impact |
| c.100C>T | missense | <0.1% | Reported in COSMIC |
Mutation functional classification
Loss of Function (LOF)
Not well characterized; likely disrupts nucleosome assembly.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • nucleosome assembly | • chromatin silencing |
| • DNA packaging | • protein heterodimerization activity |
| • histone binding |
Pathways
• Chromatin organization
• Nucleosome assembly
• Epigenetic regulation of gene expression
Protein Summary
Histone H4 is a highly conserved basic nuclear protein that forms the core of nucleosomes. It undergoes various post-translational modifications (e.g., acetylation, methylation) that regulate chromatin structure and gene expression. H4C16 encodes one of multiple replication-dependent histone H4 variants.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| H4C16 Knockout HEK293 Cell Line | EDJ-KQ13721 | Human | 121504 | Details Get a Quote |
| H4C16 Knockout A-549 Cell Line | EDJ-KQ43461 | Human | 121504 | Details Get a Quote |
| H4C16 Knockout HCT 116 Cell Line | EDJ-KQ43462 | Human | 121504 | Details Get a Quote |
| H4C16 Knockout HeLa Cell Line | EDJ-KQ43463 | Human | 121504 | Details Get a Quote |
