H3C11: Histone H3.1 Cluster Member 11
A replication-dependent histone gene encoding the H3.1 core histone variant, essential for nucleosome assembly and chromatin structure.
Gene Information Card
| Symbol | H3C11 |
|---|---|
| Full Name | H3 clustered histone 11 |
| Gene Type | Protein coding |
| Chromosomal Location | 6p22.1 |
| NCBI Gene ID | 8358 ncbi.nlm.nih.gov/gene/8358 |
| Ensembl ID | ENSG00000277791 |
| UniProt ID | P68431 |
| OMIM ID | 602811 |
| HGNC ID | 4764 |
| Aliases | HIST1H3J, H3/j, H3.1 |
Description
H3C11 is a replication-dependent histone gene located in the histone cluster 1 on chromosome 6p22.1. It encodes the H3.1 core histone protein, a component of the nucleosome. H3.1 is deposited during DNA replication and is essential for chromatin packaging, gene regulation, and genome stability. The protein contains a canonical histone fold domain and is subject to numerous post-translational modifications that influence epigenetic signaling.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (pan-cancer) | Altered H3.1 expression or mutation can disrupt nucleosome stability and chromatin accessibility, contributing to oncogenesis. | COSMIC; ClinVar |
| Pediatric high-grade glioma (H3.1 G34R/V) | Recurrent somatic mutations in H3F3A (related H3.3) are well-documented; H3C11 mutations are rare but may similarly affect histone modification. | ClinVar; OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Bone marrow | 8.2 | Low |
| Lymph node | 6.1 | Low |
| Spleen | 5.4 | Low |
| Other tissues | <5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.3 | Moderate expression |
| K562 | 10.1 | Low expression |
| HEK293 | 8.7 | Low expression |
| HepG2 | 6.4 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.103G>A (p.Gly35Arg) | Missense | <0.1% | Unknown functional impact; predicted to affect histone fold domain |
| c.248A>G (p.Gln83Arg) | Missense | <0.1% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in H3C11.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in H3C11.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported in H3C11.
View complete mutation data：
Gene Ontology (GO)
| • nucleosome assembly | • chromatin organization |
| • DNA binding | • protein heterodimerization activity |
| • nucleus |
Pathways
• Chromatin organization
• Packaging of telomere ends
• Senescence-associated secretory phenotype (SASP)
Protein Summary
The H3C11 gene encodes histone H3.1, a core histone protein that forms the nucleosome octamer with H2A, H2B, and H4. H3.1 is replication-dependent and expressed during S phase. It contains a conserved histone fold domain and is subject to post-translational modifications such as acetylation, methylation, and phosphorylation, which regulate chromatin dynamics and gene expression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| H3C11 Knockout HEK293 Cell Line | EDJ-KQ6206 | Human | 8354 | Details Get a Quote |
| H3C11 Knockout HeLa Cell Line | EDJ-KQ54874 | Human | 8354 | Details Get a Quote |
| H3C11 Knockout A-549 Cell Line | EDJ-KQ63361 | Human | 8354 | Details Get a Quote |
| H3C11 Knockout HCT 116 Cell Line | EDJ-KQ71830 | Human | 8354 | Details Get a Quote |
