H1-10 (Histone Cluster 1 H1 Family Member 10)
Linker histone H1.10, a chromatin structural protein involved in DNA compaction and gene regulation
Gene Information Card
| Symbol | H1-10 |
|---|---|
| Full Name | H1.10 linker histone, cluster member |
| Gene Type | protein-coding |
| Chromosomal Location | 6p22.2 |
| NCBI Gene ID | 3008 ncbi.nlm.nih.gov/gene/3008 |
| Ensembl ID | ENSG00000187498 |
| UniProt ID | P10412 |
| OMIM ID | 142711 |
| HGNC ID | 4716 |
| Aliases | HIST1H1E, H1.4, H1e, H1F4 |
Description
H1-10 (also known as HIST1H1E) encodes a member of the histone H1 family, which functions as a linker histone in chromatin. H1 proteins bind to linker DNA between nucleosomes, facilitating higher-order chromatin compaction and regulating gene expression. H1-10 is expressed in various tissues and is implicated in cell cycle control, differentiation, and cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Rahman syndrome | Heterozygous loss-of-function mutations in H1-10 cause a neurodevelopmental disorder with intellectual disability and facial dysmorphism | ClinVar, OMIM |
| Breast cancer | Overexpression of H1-10 is associated with poor prognosis and altered chromatin structure | COSMIC, PubMed |
| Colorectal cancer | Somatic mutations and altered expression of H1-10 contribute to tumor progression | COSMIC, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Bone marrow | 10.2 | Medium |
| Spleen | 9.8 | Medium |
| Testis | 8.1 | Medium |
| Brain | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K562 | 15.3 | Leukemia cell line |
| HeLa | 12.1 | Cervical cancer cell line |
| A549 | 9.7 | Lung cancer cell line |
| MCF7 | 8.5 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.435_438delAGAG | Frameshift | Rare | Loss of function; associated with Rahman syndrome |
| p.Arg154His | Missense | <0.01% | Unknown functional impact |
| p.Gly102Ser | Missense | <0.01% | Reported in COSMIC for colorectal cancer |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations in H1-10 lead to haploinsufficiency, causing Rahman syndrome.
Gain of Function (GOF)
No clear gain-of-function mutations reported.
Dominant Negative (DN)
Some missense variants may act in a dominant-negative manner, but evidence is limited.
View complete mutation data：
Gene Ontology (GO)
| • nucleosome binding | • DNA binding |
| • chromatin binding | • nucleus |
| • chromosome | • nucleosome assembly |
| • chromatin condensation |
Pathways
• Chromatin organization
• Telomere maintenance
• Cell cycle
Protein Summary
Histone H1.10 is a 219-amino-acid linker histone protein with a central globular domain and unstructured N- and C-terminal tails. It binds to the linker DNA between nucleosomes, promoting chromatin compaction and influencing transcription, replication, and repair. Post-translational modifications (e.g., phosphorylation, acetylation) regulate its dynamic interactions with chromatin.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| H1-10 Knockout HEK293 Cell Line | EDJ-KQ6416 | Human | 8971 | Details Get a Quote |
| H1-10 Knockout HCT 116 Cell Line | EDJ-KQ29132 | Human | 8971 | Details Get a Quote |
| H1-10 Knockout A-549 Cell Line | EDJ-KQ30461 | Human | 8971 | Details Get a Quote |
| H1-10 Knockout HeLa Cell Line | EDJ-KQ30463 | Human | 8971 | Details Get a Quote |
