GTF3C6 Gene - General Transcription Factor IIIC Subunit 6
Essential component of RNA polymerase III transcription initiation complex
Gene Information Card
| Symbol | GTF3C6 |
|---|---|
| Full Name | General Transcription Factor IIIC Subunit 6 |
| Gene Type | Protein coding |
| Chromosomal Location | 6q21 |
| NCBI Gene ID | 112495 ncbi.nlm.nih.gov/gene/112495 |
| Ensembl ID | ENSG00000112414 |
| UniProt ID | Q9Y5Q8 |
| OMIM ID | 604892 |
| HGNC ID | 4666 |
| Aliases | TFIIIC90, TF3C-6, TFIIIC-6 |
Description
GTF3C6 encodes the 90 kDa subunit of the general transcription factor IIIC (TFIIIC) complex, which is essential for RNA polymerase III-mediated transcription of small non-coding RNAs including tRNAs, 5S rRNA, and U6 snRNA. The subunit participates in promoter recognition and complex assembly.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease association reported in ClinVar or OMIM | Not applicable | Not applicable |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lymph node | 10.2 | Medium |
| Spleen | 9.8 | Medium |
| Bone marrow | 8.5 | Low |
| Brain | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K562 | 15.0 | Leukemia cell line |
| HeLa | 12.3 | Cervical carcinoma |
| HepG2 | 10.1 | Hepatocellular carcinoma |
| A549 | 9.5 | Lung carcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic mutations reported in ClinVar or COSMIC | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No documented loss-of-function variants
Gain of Function (GOF)
No documented gain-of-function variants
Dominant Negative (DN)
No documented dominant-negative variants
View complete mutation data：
Gene Ontology (GO)
Pathways
• RNA polymerase III transcription (Reactome: R-HSA-76061)
• TFIIIC complex assembly (Reactome: R-HSA-76066)
Protein Summary
GTF3C6 encodes a 90 kDa subunit of the TFIIIC complex. The protein contains a conserved domain for DNA binding and interacts with other TFIIIC subunits to recognize promoter elements of RNA polymerase III genes. It is ubiquitously expressed with higher levels in lymphoid tissues and testis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GTF3C6 Knockout HEK293 Cell Line | EDJ-KQ7385 | Human | 112495 | Details Get a Quote |
| GTF3C6 Knockout A-549 Cell Line | EDJ-KQ32526 | Human | 112495 | Details Get a Quote |
| GTF3C6 Knockout HCT 116 Cell Line | EDJ-KQ32527 | Human | 112495 | Details Get a Quote |
| GTF3C6 Knockout HeLa Cell Line | EDJ-KQ32528 | Human | 112495 | Details Get a Quote |
