GTF3C3 Gene - General Transcription Factor IIIC Subunit 3
Essential component of RNA polymerase III transcription initiation complex
Gene Information Card
| Symbol | GTF3C3 |
|---|---|
| Full Name | General Transcription Factor IIIC Subunit 3 |
| Gene Type | Protein coding |
| Chromosomal Location | 2q33.1 |
| NCBI Gene ID | 9330 ncbi.nlm.nih.gov/gene/9330 |
| Ensembl ID | ENSG00000115539 |
| UniProt ID | Q9Y5Q9 |
| OMIM ID | 604888 |
| HGNC ID | 4666 |
| Aliases | TFIIIC90, TF3C-90, TFIIIC-90 |
Description
GTF3C3 encodes the 90 kDa subunit of the general transcription factor IIIC (TFIIIC) complex, which is essential for RNA polymerase III-mediated transcription of small non-coding RNAs such as tRNAs, 5S rRNA, and U6 snRNA. The protein directly binds to the TFIIIC complex and facilitates promoter recognition and transcription initiation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease association reported in ClinVar or OMIM | Not applicable | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.8 | Medium |
| Lymph node | 10.5 | Medium |
| Spleen | 9.2 | Medium |
| Brain | 6.1 | Low |
| Liver | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.2 | High expression |
| HeLa | 12.0 | Medium expression |
| K562 | 8.5 | Medium expression |
| HepG2 | 6.7 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No somatic mutations reported in COSMIC | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
Pathways
• RNA polymerase III transcription initiation (Reactome: R-HSA-76071)
• Transcription of tRNA (Reactome: R-HSA-72086)
Protein Summary
GTF3C3 is a 90 kDa subunit of the TFIIIC complex. It contains a conserved domain that mediates interaction with other TFIIIC subunits and is required for promoter recognition and transcription initiation by RNA polymerase III. The protein is ubiquitously expressed with highest levels in testis and lymphoid tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| No Data | ||||
