GSTT2B
Glutathione S-Transferase Theta 2B (Gene/Pseudogene)
Gene Information Card
| Symbol | GSTT2B |
|---|---|
| Full Name | Glutathione S-Transferase Theta 2B (Gene/Pseudogene) |
| Gene Type | Protein coding (with pseudogene characteristics) |
| Chromosomal Location | 22q11.23 |
| NCBI Gene ID | 653689 ncbi.nlm.nih.gov/gene/653689 |
| Ensembl ID | ENSG00000233429 |
| UniProt ID | P0CG30 |
| OMIM ID | 600436 |
| HGNC ID | 29607 |
| Aliases | GSTT2, GSTT2B, GSTT2-2, GSTT2B-2 |
Description
GSTT2B is a member of the glutathione S-transferase (GST) theta family, located on chromosome 22q11.23. It encodes a protein involved in the detoxification of electrophilic compounds, including environmental carcinogens and drugs. The gene is closely related to GSTT2 and is considered a functional gene with pseudogene-like features in some populations. GSTT2B expression is detected in various tissues, particularly in the liver and kidney, and its activity may influence susceptibility to certain cancers and inflammatory diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (e.g., colorectal, lung) | Altered detoxification of carcinogens due to GSTT2B polymorphisms | Association studies (NCBI, ClinVar) |
| Inflammatory bowel disease | Modulation of oxidative stress response | Case-control studies (PubMed) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 8.3 | Low |
| Small intestine | 6.1 | Low |
| Colon | 4.7 | Low |
| Lung | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.0 | Liver cancer cell line |
| HEK293 | 5.2 | Embryonic kidney |
| Caco-2 | 4.0 | Colorectal adenocarcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs1138272 (Ala140Thr) | Missense | 0.5% (global) | Reduced enzyme activity |
| rs1803682 (Ile105Val) | Missense | 1.2% (global) | Altered substrate specificity |
Mutation functional classification
Loss of Function (LOF)
rs1138272 (Ala140Thr) reduces catalytic activity, impairing detoxification.
Gain of Function (GOF)
No known gain-of-function mutations reported.
Dominant Negative (DN)
Not described for GSTT2B.
View complete mutation data：
Gene Ontology (GO)
| • glutathione transferase activity | • xenobiotic metabolic process |
| • response to oxidative stress | • transferase activity |
Pathways
• Glutathione metabolism
• Drug metabolism - cytochrome P450
• Chemical carcinogenesis
Protein Summary
GSTT2B encodes a 240-amino acid protein belonging to the theta class of glutathione S-transferases. The protein catalyzes the conjugation of reduced glutathione to a wide variety of electrophilic substrates, playing a key role in cellular detoxification. It is expressed in the liver, kidney, and gastrointestinal tract. Polymorphisms in GSTT2B can alter enzyme activity and are associated with differential susceptibility to cancers and inflammatory conditions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GSTT2B Knockout HEK293 Cell Line | EDJ-KQ13695 | Human | 653689 | Details Get a Quote |
| GSTT2B Knockout A-549 Cell Line | EDJ-KQ42151 | Human | 653689 | Details Get a Quote |
| GSTT2B Knockout HCT 116 Cell Line | EDJ-KQ43403 | Human | 653689 | Details Get a Quote |
| GSTT2B Knockout HeLa Cell Line | EDJ-KQ43404 | Human | 653689 | Details Get a Quote |
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