GSTT2: Glutathione S-Transferase Theta 2
A member of the theta class of glutathione S-transferases involved in xenobiotic metabolism and detoxification.
Gene Information Card
| Symbol | GSTT2 |
|---|---|
| Full Name | Glutathione S-Transferase Theta 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 22q11.23 |
| NCBI Gene ID | 2953 ncbi.nlm.nih.gov/gene/2953 |
| Ensembl ID | ENSG00000100299 |
| UniProt ID | P0CG30 |
| OMIM ID | 600436 |
| HGNC ID | 4642 |
| Aliases | GSTT2-2, GSTT2B, MGC142138 |
Description
GSTT2 encodes a member of the theta class of glutathione S-transferases (GSTs). These enzymes catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds, playing a key role in cellular detoxification and protection against oxidative stress. GSTT2 is expressed in multiple tissues and is involved in the metabolism of xenobiotics, including carcinogens and therapeutic drugs.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Asthma | GSTT2 polymorphisms may alter detoxification of environmental pollutants, affecting asthma susceptibility. | NCBI Gene, ClinVar |
| Cancer (various) | GSTT2 copy number loss or reduced expression is associated with increased risk of certain cancers due to impaired detoxification. | COSMIC, NCBI Gene |
| Drug-induced liver injury | Variants in GSTT2 may affect metabolism of drugs, leading to hepatotoxicity. | ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 8.3 | Medium |
| Small intestine | 6.1 | Low |
| Lung | 4.7 | Low |
| Heart | 1.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 10.2 | Hepatocellular carcinoma cell line |
| A549 | 5.8 | Lung adenocarcinoma cell line |
| HEK293 | 3.4 | Embryonic kidney cells |
| MCF7 | 1.1 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.419C>T (p.Pro140Leu) | Missense | 0.01% | Reduced enzyme activity |
| c.1A>G (p.Met1Val) | Start loss | 0.005% | Loss of protein expression |
| c.112G>A (p.Gly38Ser) | Missense | 0.02% | Altered substrate specificity |
Mutation functional classification
Loss of Function (LOF)
c.1A>G (p.Met1Val) leads to loss of protein expression.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Glutathione metabolism (KEGG: hsa00480)
• Metabolism of xenobiotics by cytochrome P450 (KEGG: hsa00980)
• Drug metabolism - cytochrome P450 (KEGG: hsa00982)
Protein Summary
GSTT2 is a 244-amino acid protein belonging to the theta class of glutathione S-transferases. It forms a homodimer and catalyzes the conjugation of glutathione to various electrophilic substrates, including environmental carcinogens and chemotherapeutic agents. The protein is primarily cytosolic and expressed in detoxification organs such as liver and kidney.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GSTT2 Knockout HeLa Cell Line | EDJ-KQ28 | Human | 2953 | Details Get a Quote |
| GSTT2B Knockout HEK293 Cell Line | EDJ-KQ13695 | Human | 653689 | Details Get a Quote |
| GSTT2B Knockout A-549 Cell Line | EDJ-KQ42151 | Human | 653689 | Details Get a Quote |
| GSTT2B Knockout HCT 116 Cell Line | EDJ-KQ43403 | Human | 653689 | Details Get a Quote |
| GSTT2B Knockout HeLa Cell Line | EDJ-KQ43404 | Human | 653689 | Details Get a Quote |
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