GRIK3 (Glutamate Ionotropic Receptor Kainate Type Subunit 3)
A kainate-type glutamate receptor subunit involved in synaptic transmission and neuropsychiatric disorders.
Gene Information Card
| Symbol | GRIK3 |
|---|---|
| Full Name | Glutamate Ionotropic Receptor Kainate Type Subunit 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 1p34.3 |
| NCBI Gene ID | 2899 ncbi.nlm.nih.gov/gene/2899 |
| Ensembl ID | ENSG00000163873 |
| UniProt ID | Q13003 |
| OMIM ID | 138243 |
| HGNC ID | 4581 |
| Aliases | GluK3, GluR7, EAA5 |
Description
GRIK3 encodes the GluK3 subunit of kainate-type ionotropic glutamate receptors. These receptors mediate excitatory neurotransmission and are involved in synaptic plasticity, learning, and memory. GRIK3 is expressed in the central nervous system and has been implicated in neuropsychiatric disorders such as schizophrenia and bipolar disorder.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Schizophrenia | Altered glutamatergic signaling; GRIK3 polymorphisms associated with risk | ClinVar, OMIM |
| Bipolar Disorder | Dysregulation of kainate receptor function; genetic association studies | ClinVar, OMIM |
| Intellectual Disability | Rare variants affecting receptor function | ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain (cerebral cortex) | 8.2 | Medium |
| Brain (cerebellum) | 6.5 | Medium |
| Brain (hippocampus) | 7.1 | Medium |
| Testis | 1.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y | 5.4 | Neuroblastoma cell line |
| U-87 MG | 2.1 | Glioblastoma cell line |
| HEK293 | 0.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1966G>A (p.Val656Ile) | missense | <0.01% | Unknown functional effect; reported in ClinVar |
| c.1129C>T (p.Arg377Cys) | missense | <0.01% | Potential loss of function; associated with intellectual disability |
Mutation functional classification
Loss of Function (LOF)
Missense variants (e.g., p.Arg377Cys) may reduce receptor activity.
Gain of Function (GOF)
Not well documented for GRIK3.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • ionotropic glutamate receptor activity | • kainate selective glutamate receptor activity |
| • glutamate-gated calcium ion channel activity | • synaptic transmission |
| • glutamatergic | • plasma membrane |
Pathways
• Glutamatergic synapse
• Neuroactive ligand-receptor interaction
• Kainate receptor signaling
Protein Summary
GRIK3 encodes the GluK3 subunit, which assembles into homomeric or heteromeric kainate receptors. These receptors are ligand-gated ion channels that mediate fast excitatory neurotransmission. The protein contains an extracellular ligand-binding domain, transmembrane domains, and a C-terminal domain involved in receptor trafficking and synaptic localization.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GRIK3 Knockout HEK293 Cell Line | EDJ-KQ4795 | Human | 2899 | Details Get a Quote |
| GRIK3 Knockout HeLa Cell Line | EDJ-KQ53426 | Human | 2899 | Details Get a Quote |
| GRIK3 Knockout A-549 Cell Line | EDJ-KQ61903 | Human | 2899 | Details Get a Quote |
| GRIK3 Knockout HCT 116 Cell Line | EDJ-KQ70383 | Human | 2899 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
