GPX7: Glutathione Peroxidase 7 – Oxidative Stress Sensor and Tumor Suppressor
Comprehensive gene card for GPX7, including genomic annotation, expression, disease associations, and functional classification.
Gene Information Card
| Symbol | GPX7 |
|---|---|
| Full Name | Glutathione Peroxidase 7 |
| Gene Type | Protein-coding |
| Chromosomal Location | 1p32.3 |
| NCBI Gene ID | 2882 ncbi.nlm.nih.gov/gene/2882 |
| Ensembl ID | ENSG00000116157 |
| UniProt ID | Q96SL4 |
| OMIM ID | 612098 |
| HGNC ID | 4558 |
| Aliases | GPX6, GPx-7, GSHPx-7, NPGPx |
Description
GPX7 encodes glutathione peroxidase 7, a selenium-independent peroxidase that reduces hydrogen peroxide and organic hydroperoxides. It functions as a sensor of oxidative stress and plays a role in protecting cells from oxidative damage. GPX7 is also implicated in tumor suppression, particularly in esophageal adenocarcinoma, where loss of expression correlates with poor prognosis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Esophageal Adenocarcinoma | Loss of GPX7 expression leads to increased oxidative stress and DNA damage, promoting tumorigenesis. | PMID: 23431130, PMID: 25670082 |
| Barrett's Esophagus | Reduced GPX7 levels are associated with progression from Barrett's metaplasia to adenocarcinoma. | PMID: 25670082 |
| Hepatocellular Carcinoma | GPX7 downregulation contributes to oxidative stress and malignant transformation. | PMID: 28723891 |
| Breast Cancer | GPX7 hypermethylation and reduced expression are observed in breast cancer cell lines. | PMID: 21573163 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Esophagus | 12.5 | Medium |
| Liver | 8.3 | Medium |
| Kidney | 6.1 | Low |
| Breast | 4.7 | Low |
| Stomach | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| OE33 (esophageal adenocarcinoma) | 2.1 | Low expression compared to normal esophageal epithelium |
| HepG2 (hepatocellular carcinoma) | 5.8 | Moderate expression |
| MCF7 (breast cancer) | 1.5 | Low expression due to promoter methylation |
| HEK293 (embryonic kidney) | 7.4 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.1% | Likely loss of start codon; predicted loss of function |
| c.202C>T (p.Arg68Trp) | Missense | <0.1% | Located in catalytic domain; may impair peroxidase activity |
| c.344G>A (p.Arg115His) | Missense | <0.1% | Uncertain significance; reported in ClinVar |
Mutation functional classification
Loss of Function (LOF)
Loss-of-function mutations (e.g., start codon loss, catalytic domain missense) reduce peroxidase activity, leading to increased oxidative stress and potential tumor promotion.
Gain of Function (GOF)
No gain-of-function mutations have been reported for GPX7.
Dominant Negative (DN)
No dominant-negative mutations have been characterized for GPX7.
View complete mutation data：
Gene Ontology (GO)
| • glutathione peroxidase activity (GO:0004602) | • thioredoxin peroxidase activity (GO:0008379) |
| • cell redox homeostasis (GO:0045454) | • response to oxidative stress (GO:0006979) |
| • cytoplasm (GO:0005737) | • endoplasmic reticulum (GO:0005783) |
Pathways
• Glutathione metabolism (Reactome: R-HSA-174403)
• Detoxification of Reactive Oxygen Species (Reactome: R-HSA-3299685)
• Oxidative Stress Induced Senescence (WikiPathways: WP3875)
Protein Summary
GPX7 is a 187-amino acid protein (molecular weight ~21 kDa) localized to the cytoplasm and endoplasmic reticulum. It contains a conserved thioredoxin-like fold and a catalytic cysteine residue (Cys57) instead of selenocysteine, distinguishing it from selenium-dependent GPX family members. GPX7 reduces H2O2 and phospholipid hydroperoxides, protecting cells from oxidative damage. It also interacts with other redox proteins such as PRDX6 and TXN. Loss of GPX7 expression is a hallmark of several cancers, particularly esophageal adenocarcinoma.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPX7 Knockout HEK293 Cell Line | EDJ-KQ4793 | Human | 2882 | Details Get a Quote |
| GPX7 Knockout HeLa Cell Line | EDJ-KQ27560 | Human | 2882 | Details Get a Quote |
| GPX7 Knockout A-549 Cell Line | EDJ-KQ61894 | Human | 2882 | Details Get a Quote |
| GPX7 Knockout HCT 116 Cell Line | EDJ-KQ70375 | Human | 2882 | Details Get a Quote |
