GPS2 Gene - G Protein Pathway Suppressor 2
Comprehensive genomic and functional overview of GPS2
Gene Information Card
| Symbol | GPS2 |
|---|---|
| Full Name | G protein pathway suppressor 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 17p13.1 |
| NCBI Gene ID | 2874 ncbi.nlm.nih.gov/gene/2874 |
| Ensembl ID | ENSG00000132522 |
| UniProt ID | Q13227 |
| OMIM ID | 601935 |
| HGNC ID | 4552 |
| Aliases | AMF-1, GPS2, MGC104231 |
Description
GPS2 (G protein pathway suppressor 2) encodes a protein that functions as a transcriptional repressor and is a component of the NCoR/SMRT corepressor complex. It plays a role in regulating G protein signaling, cell proliferation, and apoptosis. The gene is located on chromosome 17p13.1 and is involved in various cellular processes including DNA repair and lipid metabolism.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | GPS2 downregulation correlates with poor prognosis; loss promotes tumor growth via NF-κB activation | PMID: 25605249 |
| Breast cancer | GPS2 mutations and altered expression linked to tumor progression | COSMIC |
| Colorectal cancer | Reduced GPS2 expression associated with metastasis and worse survival | PMID: 28411380 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Breast | 8.2 | Low |
| Colon | 10.1 | Medium |
| Lung | 9.8 | Low |
| Kidney | 11.3 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 14.0 | Hepatocellular carcinoma cell line |
| MCF7 | 9.5 | Breast cancer cell line |
| HCT116 | 11.2 | Colorectal carcinoma cell line |
| A549 | 10.0 | Lung carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown |
| c.200C>T | Nonsense | <0.01% | Predicted loss of function |
| c.350G>A | Missense | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations in GPS2 are predicted to cause loss of function, impairing corepressor activity and leading to dysregulated transcription.
Gain of Function (GOF)
No gain-of-function mutations have been reported for GPS2.
Dominant Negative (DN)
No dominant-negative mutations have been characterized for GPS2.
View complete mutation data：
Gene Ontology (GO)
Pathways
• NCoR/SMRT corepressor complex
• NF-κB signaling pathway
• G protein signaling
Protein Summary
GPS2 encodes a 327-amino acid protein that acts as a transcriptional corepressor. It is a stable component of the NCoR/SMRT complex, mediating repression of nuclear hormone receptor and NF-κB target genes. The protein also participates in DNA damage response and lipid homeostasis. Its dysregulation is implicated in several cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPS2 Knockout HEK293 Cell Line | EDJ-KQ2993 | Human | 2874 | Details Get a Quote |
| GPS2 Knockout A-549 Cell Line | EDJ-KQ24176 | Human | 2874 | Details Get a Quote |
| GPS2 Knockout HCT 116 Cell Line | EDJ-KQ24177 | Human | 2874 | Details Get a Quote |
| GPS2 Knockout HeLa Cell Line | EDJ-KQ24178 | Human | 2874 | Details Get a Quote |
