GPR83: G Protein-Coupled Receptor 83
Orphan GPCR with roles in immune regulation and cancer
Gene Information Card
| Symbol | GPR83 |
|---|---|
| Full Name | G protein-coupled receptor 83 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q21 |
| NCBI Gene ID | 10888 ncbi.nlm.nih.gov/gene/10888 |
| Ensembl ID | ENSG00000148773 |
| UniProt ID | Q9NYM4 |
| OMIM ID | 605569 |
| HGNC ID | 4526 |
| Aliases | GIR, GPR72, MGC129621 |
Description
GPR83 (G protein-coupled receptor 83) is an orphan GPCR with high expression in the brain and immune tissues. It is involved in neuroendocrine regulation, immune modulation, and has been implicated in cancer progression. The receptor is a class A rhodopsin-like GPCR and is conserved across vertebrates.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Glioblastoma | Potential role in tumor growth and immune evasion; GPR83 expression correlates with poor prognosis | PMID: 31085175 |
| Breast cancer | Overexpression in tumor tissues; may promote metastasis via GPCR signaling | PMID: 29445144 |
| Inflammatory bowel disease | GPR83 expression altered in inflamed mucosa; possible role in T-cell regulation | PMID: 25687263 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lymph node | 8.3 | Medium |
| Spleen | 7.1 | Medium |
| Testis | 6.8 | Low |
| Liver | 1.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.2 | Recombinant expression studies |
| Jurkat | 7.5 | T-cell line |
| U87MG | 9.8 | Glioblastoma cell line |
| MCF7 | 6.4 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Cys) | Missense | <0.01% | Unknown; predicted benign by SIFT |
| c.457G>A (p.Val153Met) | Missense | <0.01% | Unknown; predicted possibly damaging by PolyPhen |
| c.784_786del (p.Phe262del) | In-frame deletion | <0.01% | Unknown; may affect receptor conformation |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity (GO:0004930) | • signal transduction (GO:0007165) |
| • plasma membrane (GO:0005886) | • neuropeptide signaling pathway (GO:0007218) |
Pathways
• GPCR downstream signaling (Reactome: R-HSA-372790)
• Peptide ligand-binding receptors (Reactome: R-HSA-375276)
Protein Summary
GPR83 is a 422-amino acid orphan GPCR with seven transmembrane domains. It shares homology with neuropeptide receptors and is thought to bind an as-yet-unidentified endogenous ligand. The protein is expressed on the cell surface and activates G-protein signaling pathways, including cAMP modulation. Structural studies suggest a conserved ligand-binding pocket typical of class A GPCRs.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPR83 Knockout HEK293 Cell Line | EDJ-KQ7204 | Human | 10888 | Details Get a Quote |
| GPR83 Knockout HeLa Cell Line | EDJ-KQ55517 | Human | 10888 | Details Get a Quote |
| GPR83 Knockout A-549 Cell Line | EDJ-KQ64007 | Human | 10888 | Details Get a Quote |
| GPR83 Knockout HCT 116 Cell Line | EDJ-KQ72458 | Human | 10888 | Details Get a Quote |
