GPR63: G Protein-Coupled Receptor 63
Orphan receptor with potential roles in neurodevelopment and cancer
Gene Information Card
| Symbol | GPR63 |
|---|---|
| Full Name | G protein-coupled receptor 63 |
| Gene Type | protein-coding |
| Chromosomal Location | 6q16.1 |
| NCBI Gene ID | 81490 ncbi.nlm.nih.gov/gene/81490 |
| Ensembl ID | ENSG00000112414 |
| UniProt ID | Q9BZJ4 |
| OMIM ID | 607410 |
| HGNC ID | 4500 |
| Aliases | PSP24B, GPR63 |
Description
GPR63 encodes an orphan G protein-coupled receptor (GPCR) belonging to the rhodopsin-like family. It is expressed in brain, testis, and various cancer cell lines. The receptor may couple to Gs and Gi/o proteins, influencing cAMP signaling. Its endogenous ligand remains unidentified, but it is implicated in neurodevelopment and tumorigenesis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Schizophrenia | Potential involvement via altered cAMP signaling in neurons; GPR63 expression changes observed in postmortem brain studies | PMID: 19012866 |
| Glioblastoma | Overexpression in glioma tissues; may promote cell proliferation through MAPK pathway activation | PMID: 23469117 |
| Prostate cancer | Upregulated in prostate cancer cell lines; possible role in androgen-independent growth | PMID: 21573172 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.3 | Medium |
| Testis | 8.7 | Low |
| Prostate | 5.2 | Low |
| Lung | 3.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.6 | Recombinant overexpression studies |
| U87MG (glioblastoma) | 22.4 | Endogenous expression |
| LNCaP (prostate cancer) | 9.8 | Androgen-sensitive |
| PC3 (prostate cancer) | 14.1 | Androgen-independent |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | <0.01% | Unknown; rare variant in population databases |
| c.452G>A (p.Arg151His) | Missense | <0.01% | Predicted benign by in silico tools |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in literature.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity (GO:0004930) | • G protein-coupled receptor signaling pathway (GO:0007186) |
| • plasma membrane (GO:0005886) | • integral component of membrane (GO:0016021) |
Pathways
• GPCR downstream signaling (Reactome: R-HSA-388396)
• Gs-mediated signaling (Reactome: R-HSA-400040)
Protein Summary
GPR63 is a 377-amino acid orphan GPCR with seven transmembrane domains. It shares homology with the PSP24 family. The receptor is predominantly localized to the plasma membrane and can activate both Gs and Gi/o pathways, modulating intracellular cAMP levels. Its expression in brain and testis suggests roles in neurodevelopment and reproduction. In cancer, GPR63 overexpression correlates with aggressive phenotypes, particularly in glioblastoma and prostate cancer.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPR63 Knockout HEK293 Cell Line | EDJ-KQ9700 | Human | 81491 | Details Get a Quote |
| GPR63 Knockout HCT 116 Cell Line | EDJ-KQ36470 | Human | 81491 | Details Get a Quote |
| GPR63 Knockout HeLa Cell Line | EDJ-KQ57388 | Human | 81491 | Details Get a Quote |
| GPR63 Knockout A-549 Cell Line | EDJ-KQ65894 | Human | 81491 | Details Get a Quote |
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