GPR62: G Protein-Coupled Receptor 62
Orphan GPCR with potential roles in neurobiology and cancer
Gene Information Card
| Symbol | GPR62 |
|---|---|
| Full Name | G protein-coupled receptor 62 |
| Gene Type | protein-coding |
| Chromosomal Location | 3p21.31 |
| NCBI Gene ID | 118442 ncbi.nlm.nih.gov/gene/118442 |
| Ensembl ID | ENSG00000170962 |
| UniProt ID | Q9BZJ6 |
| OMIM ID | 612531 |
| HGNC ID | 4529 |
| Aliases | GPCR62, KPG_001 |
Description
GPR62 is an orphan G protein-coupled receptor (GPCR) encoded by the GPR62 gene located on chromosome 3p21.31. The protein belongs to the class A rhodopsin-like GPCR family. Its endogenous ligand remains unknown, but it is implicated in neurobiological processes and has been studied in the context of cancer due to its expression in certain tumor types. GPR62 is expressed in brain regions and peripheral tissues, and its signaling may involve G protein activation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Potential role in tumorigenesis via GPCR signaling; expression changes observed in some cancers | COSMIC database reports somatic mutations in cancer samples; limited direct evidence |
| Neurological disorders | Expression in brain suggests possible involvement in neuropsychiatric conditions | Inferred from tissue expression; no direct disease association in OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 0.8 | Low |
| Testis | 0.5 | Low |
| Lung | 0.3 | Not detected |
| Liver | 0.2 | Not detected |
| Kidney | 0.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.6 | Low expression; used in heterologous expression studies |
| SH-SY5Y | 0.4 | Neuroblastoma cell line; low expression |
| A549 | 0.2 | Lung carcinoma; very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100G>A (p.Val34Ile) | Missense | 0.01% | Unknown; rare variant in population databases |
| c.200C>T (p.Thr67Met) | Missense | 0.005% | Unknown; reported in COSMIC as somatic in cancer |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity (GO:0004930) | • plasma membrane (GO:0005886) |
| • signal transduction (GO:0007165) |
Pathways
• GPCR downstream signaling (Reactome: R-HSA-372790)
Protein Summary
GPR62 is a 365-amino acid orphan GPCR with seven transmembrane domains. It is predicted to couple to G proteins, but its specific signaling cascade and ligand remain unidentified. The protein is expressed at low levels in brain and testis, and its function may be relevant to neurobiology and cancer biology.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPR62 Knockout HEK293 Cell Line | EDJ-KQ7619 | Human | 118442 | Details Get a Quote |
| GPR62 Knockout HeLa Cell Line | EDJ-KQ58024 | Human | 118442 | Details Get a Quote |
| GPR62 Knockout A-549 Cell Line | EDJ-KQ66511 | Human | 118442 | Details Get a Quote |
| GPR62 Knockout HCT 116 Cell Line | EDJ-KQ74931 | Human | 118442 | Details Get a Quote |
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