GPR45
G Protein-Coupled Receptor 45
Gene Information Card
| Symbol | GPR45 |
|---|---|
| Full Name | G protein-coupled receptor 45 |
| Gene Type | protein-coding |
| Chromosomal Location | 2q11.2 |
| NCBI Gene ID | 11249 ncbi.nlm.nih.gov/gene/11249 |
| Ensembl ID | ENSG00000135929 |
| UniProt ID | Q9Y2T3 |
| OMIM ID | 604842 |
| HGNC ID | 4489 |
| Aliases | PSP24(B), PSP24-2 |
Description
GPR45 encodes a member of the G protein-coupled receptor (GPCR) family, specifically an orphan receptor with homology to the lysophosphatidic acid (LPA) receptor subfamily. The protein is involved in intracellular signaling pathways, potentially modulating cell proliferation and differentiation. Its endogenous ligand remains unidentified.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Schizophrenia | Potential involvement in neurodevelopment and signaling; altered expression observed in brain regions | OMIM 604842; NCBI Gene |
| Bipolar disorder | Possible dysregulation of GPCR signaling pathways | OMIM 604842 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Testis | 8.3 | Low |
| Kidney | 6.1 | Low |
| Liver | 4.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y | 15.0 | Neuroblastoma cell line |
| HEK293 | 10.2 | Embryonic kidney cells |
| HepG2 | 5.8 | Hepatocellular carcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | Missense | <0.01% | Unknown; predicted possibly damaging |
| c.457G>A (p.Val153Ile) | Missense | <0.01% | Unknown; predicted benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor signaling pathway | • plasma membrane |
| • integral component of membrane | • signal transduction |
Pathways
• GPCR downstream signaling
• Class A/1 (Rhodopsin-like) receptors
Protein Summary
GPR45 is a 362-amino acid orphan GPCR with seven transmembrane domains. It shares sequence similarity with LPA receptors and is expressed predominantly in the brain. The protein may play a role in neuropsychiatric disorders, though its exact function and ligand remain unknown.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPR45 Knockout HEK293 Cell Line | EDJ-KQ7350 | Human | 11250 | Details Get a Quote |
| GPR45 Knockout HeLa Cell Line | EDJ-KQ55611 | Human | 11250 | Details Get a Quote |
| GPR45 Knockout A-549 Cell Line | EDJ-KQ64110 | Human | 11250 | Details Get a Quote |
| GPR45 Knockout HCT 116 Cell Line | EDJ-KQ72555 | Human | 11250 | Details Get a Quote |
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