GPR31
G Protein-Coupled Receptor 31
Gene Information Card
| Symbol | GPR31 |
|---|---|
| Full Name | G protein-coupled receptor 31 |
| Gene Type | protein-coding |
| Chromosomal Location | 6q27 |
| NCBI Gene ID | 2853 ncbi.nlm.nih.gov/gene/2853 |
| Ensembl ID | ENSG00000112210 |
| UniProt ID | O00270 |
| OMIM ID | 602043 |
| HGNC ID | 4486 |
| Aliases | 12-HETER, HETER, MGC119894 |
Description
GPR31 encodes a G protein-coupled receptor that functions as a high-affinity receptor for 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE), a metabolite of arachidonic acid. The receptor is involved in immune cell chemotaxis, particularly of dendritic cells, and has been implicated in cancer metastasis and inflammatory responses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (metastasis) | GPR31 activation by 12(S)-HETE promotes migration and invasion of cancer cells | PMID: 24662920 |
| Inflammatory diseases | Receptor mediates chemotaxis of dendritic cells and monocytes in response to 12(S)-HETE | PMID: 21383153 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 5.2 | Medium |
| Spleen | 4.8 | Medium |
| Bone marrow | 3.1 | Low |
| Lung | 2.5 | Low |
| Small intestine | 1.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.8 | Low expression |
| THP-1 | 3.5 | Monocytic cell line; moderate expression |
| Jurkat | 2.1 | T-cell line; low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.236C>T (p.Pro79Leu) | Missense | <0.01% | Unknown functional effect |
| c.487G>A (p.Val163Ile) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • 12(S)-hydroxyeicosatetraenoic acid receptor activity |
| • plasma membrane | • signal transduction |
| • chemotaxis |
Pathways
• GPCR downstream signaling
• Arachidonic acid metabolism
• 12(S)-HETE signaling pathway
Protein Summary
GPR31 is a 319-amino acid transmembrane receptor that couples to G proteins to mediate cellular responses to 12(S)-HETE. It is predominantly expressed in immune tissues and plays a role in cell migration and inflammation. Structural studies suggest a typical GPCR fold with seven transmembrane helices.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPR31 Knockout HEK293 Cell Line | EDJ-KQ4772 | Human | 2853 | Details Get a Quote |
| GPR31 Knockout HeLa Cell Line | EDJ-KQ53405 | Human | 2853 | Details Get a Quote |
| GPR31 Knockout A-549 Cell Line | EDJ-KQ61882 | Human | 2853 | Details Get a Quote |
| GPR31 Knockout HCT 116 Cell Line | EDJ-KQ70362 | Human | 2853 | Details Get a Quote |
