GPR25: G Protein-Coupled Receptor 25
Orphan GPCR with potential roles in immune regulation and cancer
Gene Information Card
| Symbol | GPR25 |
|---|---|
| Full Name | G protein-coupled receptor 25 |
| Gene Type | protein-coding |
| Chromosomal Location | 1q31.1 |
| NCBI Gene ID | 2847 ncbi.nlm.nih.gov/gene/2847 |
| Ensembl ID | ENSG00000143190 |
| UniProt ID | Q9BXC1 |
| OMIM ID | 604531 |
| HGNC ID | 4482 |
| Aliases | GPCR25 |
Description
GPR25 encodes an orphan G protein-coupled receptor (GPCR) with no known endogenous ligand. It is expressed in immune tissues and certain cancer cell lines. The receptor may modulate cAMP signaling and is implicated in immune regulation and tumor biology.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (pan-cancer) | Altered expression; potential role in tumor microenvironment | COSMIC; TCGA expression data |
| Immune disorders | Predicted involvement in immune signaling | NCBI GeneRIF; UniProt annotation |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 2.1 | Low |
| Lymph node | 1.8 | Low |
| Bone marrow | 1.5 | Low |
| Testis | 1.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 | 0.8 | Low expression |
| HEK 293 | 0.5 | Very low expression |
| HUVEC | 0.3 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown |
| c.100C>T | missense | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor signaling pathway (GO:0007186) | • plasma membrane (GO:0005886) |
| • signal transduction (GO:0007165) |
Pathways
• GPCR downstream signaling (Reactome: R-HSA-388396)
Protein Summary
GPR25 is a 374-amino acid orphan GPCR with seven transmembrane domains. It is predicted to couple to G proteins and modulate intracellular cAMP levels. Expression is highest in lymphoid tissues, suggesting a role in immune function. No endogenous ligand has been identified.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPR25 Knockout HEK293 Cell Line | EDJ-KQ4766 | Human | 2848 | Details Get a Quote |
| GPR25 Knockout HeLa Cell Line | EDJ-KQ53401 | Human | 2848 | Details Get a Quote |
| GPR25 Knockout A-549 Cell Line | EDJ-KQ61878 | Human | 2848 | Details Get a Quote |
| GPR25 Knockout HCT 116 Cell Line | EDJ-KQ70359 | Human | 2848 | Details Get a Quote |
