GPR183: G Protein-Coupled Receptor 183
A key regulator of immune cell positioning and B cell responses
Gene Information Card
| Symbol | GPR183 |
|---|---|
| Full Name | G protein-coupled receptor 183 |
| Gene Type | protein-coding |
| Chromosomal Location | 13q32.3 |
| NCBI Gene ID | 1880 ncbi.nlm.nih.gov/gene/1880 |
| Ensembl ID | ENSG00000169508 |
| UniProt ID | O00265 |
| OMIM ID | 605741 |
| HGNC ID | 4519 |
| Aliases | EBI2, EBV-induced G protein-coupled receptor 2 |
Description
GPR183 (EBI2) is a G protein-coupled receptor that binds oxysterols such as 7α,25-dihydroxycholesterol. It plays a critical role in the positioning of B cells and dendritic cells within lymphoid organs, influencing humoral immune responses. The receptor is also implicated in Epstein-Barr virus infection and certain cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Autoimmune diseases (e.g., multiple sclerosis, rheumatoid arthritis) | Dysregulated GPR183 signaling alters immune cell migration, promoting inflammation | PMID: 27667682 |
| B-cell lymphoma | Aberrant GPR183 expression may contribute to B cell homing and tumor microenvironment interactions | PMID: 29142287 |
| Epstein-Barr virus infection | GPR183 is induced by EBV and may modulate viral latency and B cell transformation | PMID: 8391935 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 12.5 | Medium |
| Lymph node | 10.8 | Medium |
| Bone marrow | 8.2 | Low |
| Small intestine | 6.1 | Low |
| Lung | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Raji (Burkitt lymphoma) | 15.2 | EBV-positive B cell line |
| Daudi (Burkitt lymphoma) | 14.7 | EBV-positive B cell line |
| HEK293 | 1.5 | Low endogenous expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100G>A (p.Gly34Arg) | Missense | <0.01% | Reduced oxysterol binding affinity |
| c.512T>C (p.Leu171Pro) | Missense | <0.01% | Impaired cell surface expression |
Mutation functional classification
Loss of Function (LOF)
p.Gly34Arg and p.Leu171Pro reduce receptor activity or surface expression.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
Not described.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • oxysterol binding |
| • cell surface receptor signaling pathway | • positive regulation of B cell chemotaxis |
| • immune response |
Pathways
• GPCR downstream signaling
• Oxysterol-mediated immune regulation
Protein Summary
GPR183 is a 7-transmembrane G protein-coupled receptor that binds oxysterols, particularly 7α,25-dihydroxycholesterol. It is expressed on B cells, T cells, and dendritic cells, guiding their migration within lymphoid follicles. The receptor is involved in humoral immunity and has been linked to autoimmune diseases and B-cell malignancies.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPR183 Knockout HEK293 Cell Line | EDJ-KQ4494 | Human | 1880 | Details Get a Quote |
| GPR183 Knockout HeLa Cell Line | EDJ-KQ53132 | Human | 1880 | Details Get a Quote |
| GPR183 Knockout A-549 Cell Line | EDJ-KQ61605 | Human | 1880 | Details Get a Quote |
| GPR183 Knockout HCT 116 Cell Line | EDJ-KQ70094 | Human | 1880 | Details Get a Quote |
