GPR180
G Protein-Coupled Receptor 180
Gene Information Card
| Symbol | GPR180 |
|---|---|
| Full Name | G protein-coupled receptor 180 |
| Gene Type | protein-coding |
| Chromosomal Location | 13q32.1 |
| NCBI Gene ID | 160897 ncbi.nlm.nih.gov/gene/160897 |
| Ensembl ID | ENSG00000102738 |
| UniProt ID | Q86Y35 |
| OMIM ID | 612264 |
| HGNC ID | 24982 |
| Aliases | ITR, MGC138499, MGC138501 |
Description
GPR180 (G protein-coupled receptor 180) is a protein-coding gene that encodes a member of the G protein-coupled receptor family. The encoded protein is an integral membrane protein involved in intracellular signaling pathways. GPR180 is also known as ITR (intimal thickness-related receptor) and has been implicated in vascular remodeling and smooth muscle cell proliferation. Expression data suggest roles in cardiovascular and metabolic processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Coronary artery disease | Potential involvement in vascular smooth muscle cell proliferation and intimal thickening; limited direct evidence. | PMID: 15173162 |
| Obesity | Associated with body mass index in genome-wide association studies; mechanism unclear. | PMID: 25673412 |
| Type 2 diabetes | Linked to glycemic traits in GWAS; possible role in insulin signaling. | PMID: 24509480 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose tissue | 5.2 | Low |
| Artery | 8.7 | Medium |
| Heart | 6.1 | Low |
| Liver | 3.4 | Low |
| Pancreas | 4.8 | Low |
| Skeletal muscle | 2.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HUVEC (umbilical vein endothelial) | 6.5 | Moderate expression |
| Aortic smooth muscle cells | 9.1 | Higher expression |
| HepG2 (liver) | 3.2 | Low expression |
| 3T3-L1 adipocytes | 5.8 | Differentiation-dependent |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | <0.01% | Unknown functional effect |
| c.452G>A (p.Arg151Gln) | Missense | <0.01% | Unknown functional effect |
| c.788A>G (p.Asn263Ser) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • integral component of membrane |
| • signal transduction | • cell surface receptor signaling pathway |
Pathways
• GPCR downstream signaling
• cAMP signaling pathway
Protein Summary
GPR180 is a 7-transmembrane domain G protein-coupled receptor of 335 amino acids. It is predicted to couple to G proteins and modulate intracellular second messengers such as cAMP. The protein is expressed in vascular smooth muscle and adipose tissue, suggesting roles in cardiovascular and metabolic regulation. Structural studies indicate conserved GPCR motifs, but the endogenous ligand remains unknown.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPR180 Knockout HEK293 Cell Line | EDJ-KQ13671 | Human | 160897 | Details Get a Quote |
| GPR180 Knockout HCT 116 Cell Line | EDJ-KQ42116 | Human | 160897 | Details Get a Quote |
| GPR180 Knockout A-549 Cell Line | EDJ-KQ43364 | Human | 160897 | Details Get a Quote |
| GPR180 Knockout HeLa Cell Line | EDJ-KQ43365 | Human | 160897 | Details Get a Quote |
