GPR18: N-Arachidonyl Glycine Receptor and Orphan GPCR
Comprehensive gene resource for GPR18, including genomic annotation, expression, mutations, and disease associations.
Gene Information Card
| Symbol | GPR18 |
|---|---|
| Full Name | G protein-coupled receptor 18 |
| Gene Type | protein-coding |
| Chromosomal Location | 13q32.3 |
| NCBI Gene ID | 2841 ncbi.nlm.nih.gov/gene/2841 |
| Ensembl ID | ENSG00000125245 |
| UniProt ID | Q14330 |
| OMIM ID | 602042 |
| HGNC ID | 4472 |
| Aliases | DRV2, NAG receptor |
Description
GPR18 (G protein-coupled receptor 18) is a protein-coding gene located on chromosome 13q32.3. It encodes a rhodopsin-like GPCR that is activated by N-arachidonyl glycine (NAGly) and related lipid mediators. GPR18 is involved in immune regulation, cell migration, and cannabinoid signaling. It is expressed in lymphoid tissues, brain, and reproductive organs. Mutations and altered expression have been implicated in inflammatory diseases and cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Inflammatory bowel disease | Altered GPR18 signaling may modulate immune cell trafficking and cytokine release | PMID: 25687263 |
| Prostate cancer | GPR18 expression is upregulated and may promote cell proliferation via MAPK pathway | PMID: 23960097 |
| Endometriosis | GPR18 expression in endometrial tissue may influence lesion growth and inflammation | PMID: 25687263 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 12.5 | Medium |
| Lymph node | 10.2 | Medium |
| Brain (cerebellum) | 8.1 | Low |
| Testis | 15.3 | Medium |
| Lung | 5.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 18.7 | High expression; used in functional studies |
| Jurkat (T cell) | 14.2 | Moderate expression |
| HEK293 | 2.1 | Low endogenous expression; often used for transfection |
| PC3 (prostate cancer) | 22.5 | High expression; relevant to cancer studies |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | 0.01% (gnomAD) | Unknown; located in extracellular domain |
| c.682G>A (p.Val228Ile) | Missense | 0.005% (gnomAD) | Unknown; located in transmembrane domain |
| c.1003C>T (p.Arg335Trp) | Missense | 0.002% (gnomAD) | Unknown; located in intracellular C-terminus |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity (GO:0004930) | • N-arachidonyl glycine receptor activity (GO:0038045) |
| • plasma membrane (GO:0005886) | • signal transduction (GO:0007165) |
| • immune response (GO:0006955) | • cell migration (GO:0016477) |
Pathways
• GPCR downstream signaling (Reactome: R-HSA-372790)
• Cannabinoid receptor signaling (KEGG: map04726)
• MAPK signaling pathway (KEGG: map04010)
Protein Summary
GPR18 is a 331-amino acid G protein-coupled receptor with seven transmembrane domains. It is activated by N-arachidonyl glycine (NAGly) and related lipids, leading to Gi/o-mediated signaling, inhibition of cAMP, and activation of MAPK pathways. The receptor is expressed in immune cells, brain, and reproductive tissues, and plays roles in chemotaxis, cell proliferation, and inflammation. Structural studies are limited; functional data derive from heterologous expression systems.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPR183 Knockout HEK293 Cell Line | EDJ-KQ4494 | Human | 1880 | Details Get a Quote |
| GPR18 Knockout HEK293 Cell Line | EDJ-KQ4763 | Human | 2841 | Details Get a Quote |
| GPR180 Knockout HEK293 Cell Line | EDJ-KQ13671 | Human | 160897 | Details Get a Quote |
| GPR180 Knockout HCT 116 Cell Line | EDJ-KQ42116 | Human | 160897 | Details Get a Quote |
| GPR180 Knockout A-549 Cell Line | EDJ-KQ43364 | Human | 160897 | Details Get a Quote |
| GPR180 Knockout HeLa Cell Line | EDJ-KQ43365 | Human | 160897 | Details Get a Quote |
| GPR183 Knockout HeLa Cell Line | EDJ-KQ53132 | Human | 1880 | Details Get a Quote |
| GPR18 Knockout HeLa Cell Line | EDJ-KQ53394 | Human | 2841 | Details Get a Quote |
| GPR183 Knockout A-549 Cell Line | EDJ-KQ61605 | Human | 1880 | Details Get a Quote |
| GPR18 Knockout A-549 Cell Line | EDJ-KQ61872 | Human | 2841 | Details Get a Quote |
| GPR183 Knockout HCT 116 Cell Line | EDJ-KQ70094 | Human | 1880 | Details Get a Quote |
| GPR18 Knockout HCT 116 Cell Line | EDJ-KQ70353 | Human | 2841 | Details Get a Quote |
