GPR176: G Protein-Coupled Receptor 176
Orphan GPCR Involved in Circadian Rhythm and Cell Signaling
Gene Information Card
| Symbol | GPR176 |
|---|---|
| Full Name | G protein-coupled receptor 176 |
| Gene Type | protein-coding |
| Chromosomal Location | 15q14 |
| NCBI Gene ID | 11245 ncbi.nlm.nih.gov/gene/11245 |
| Ensembl ID | ENSG00000137869 |
| UniProt ID | Q14439 |
| OMIM ID | 612183 |
| HGNC ID | 4513 |
| Aliases | GPR176, Gm1010, GPCR176 |
Description
GPR176 is an orphan G protein-coupled receptor (GPCR) that modulates circadian rhythm by regulating the period length of the circadian clock. It is involved in intracellular signaling through G protein coupling and may play roles in cell proliferation, differentiation, and cancer. The gene is located on chromosome 15q14 and encodes a 7-transmembrane domain receptor.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered GPR176 expression may influence tumor growth via GPCR signaling pathways. | COSMIC; NCBI Gene |
| Colorectal cancer | Mutations and expression changes observed in colorectal tumors. | COSMIC |
| Circadian rhythm disorders | GPR176 regulates period length of circadian clock; variants may disrupt sleep-wake cycles. | OMIM; NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Liver | 4.1 | Low |
| Kidney | 6.7 | Low |
| Testis | 15.2 | Medium |
| Lung | 5.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.1 | Moderate expression |
| HeLa | 7.8 | Low expression |
| MCF7 | 14.3 | Medium expression |
| A549 | 6.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | 0.02% | Unknown functional impact |
| c.452G>A (p.Arg151His) | Missense | 0.01% | Reported in COSMIC for colorectal cancer |
| c.788delC | Frameshift | <0.01% | Loss of function predicted |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.788delC) likely cause loss of receptor function.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor signaling pathway | • circadian rhythm |
| • plasma membrane | • integral component of membrane |
| • signal transduction |
Pathways
• GPCR signaling (Rho family G proteins)
• Circadian entrainment
Protein Summary
GPR176 is a 7-transmembrane domain orphan GPCR of 376 amino acids. It is expressed in brain and testis, and modulates circadian period length. The receptor couples to G proteins to regulate intracellular signaling cascades. Its exact ligand remains unknown.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPR176 Knockout HEK293 Cell Line | EDJ-KQ7346 | Human | 11245 | Details Get a Quote |
| GPR176 Knockout HCT 116 Cell Line | EDJ-KQ31077 | Human | 11245 | Details Get a Quote |
| GPR176 Knockout A-549 Cell Line | EDJ-KQ32451 | Human | 11245 | Details Get a Quote |
| GPR176 Knockout HeLa Cell Line | EDJ-KQ32453 | Human | 11245 | Details Get a Quote |
