GPR173
G Protein-Coupled Receptor 173
Gene Information Card
| Symbol | GPR173 |
|---|---|
| Full Name | G protein-coupled receptor 173 |
| Gene Type | protein-coding |
| Chromosomal Location | Xp11.3 |
| NCBI Gene ID | 54328 ncbi.nlm.nih.gov/gene/54328 |
| Ensembl ID | ENSG00000169062 |
| UniProt ID | Q9H6A0 |
| OMIM ID | 300393 |
| HGNC ID | 4519 |
| Aliases | SREB3, MGC138499 |
Description
GPR173 encodes a member of the G protein-coupled receptor family, specifically the super-conserved receptor expressed in brain (SREB) subfamily. The protein is predominantly expressed in the central nervous system and is involved in neuroendocrine signaling, potentially regulating reproductive function and energy homeostasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Premature ovarian failure | Altered receptor signaling affecting gonadotropin regulation | PMID: 21802063 |
| Neuropsychiatric disorders | Dysregulation of SREB signaling in brain | PMID: 25644603 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain (cerebral cortex) | 12.5 | Medium |
| Pituitary gland | 8.3 | Low |
| Testis | 6.1 | Low |
| Ovary | 4.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 15.2 | High expression |
| HEK293 (embryonic kidney) | 2.1 | Low expression |
| U-87 MG (glioblastoma) | 9.8 | Medium expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | 0.001% (gnomAD) | Unknown functional effect |
| c.457G>A (p.Val153Ile) | Missense | 0.002% (gnomAD) | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • neurotransmitter receptor activity |
| • plasma membrane | • signal transduction |
| • G protein-coupled receptor signaling pathway |
Pathways
• GPCR downstream signaling
• Neuroactive ligand-receptor interaction
Protein Summary
GPR173 is a 377-amino acid integral membrane protein with seven transmembrane domains typical of GPCRs. It is highly conserved across vertebrates and is thought to modulate intracellular cAMP levels via G protein coupling. Expression is enriched in brain regions such as the hypothalamus and cortex, suggesting roles in neuroendocrine control.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPR173 Knockout HEK293 Cell Line | EDJ-KQ11402 | Human | 54328 | Details Get a Quote |
| GPR173 Knockout HCT 116 Cell Line | EDJ-KQ39614 | Human | 54328 | Details Get a Quote |
| GPR173 Knockout HeLa Cell Line | EDJ-KQ39615 | Human | 54328 | Details Get a Quote |
| GPR173 Knockout A-549 Cell Line | EDJ-KQ64898 | Human | 54328 | Details Get a Quote |
