GPR171: G Protein-Coupled Receptor 171
A comprehensive resource on GPR171 gene, expression, mutations, and associated diseases
Gene Information Card
| Symbol | GPR171 |
|---|---|
| Full Name | G protein-coupled receptor 171 |
| Gene Type | protein-coding |
| Chromosomal Location | 3q25.1 |
| NCBI Gene ID | 29909 ncbi.nlm.nih.gov/gene/29909 |
| Ensembl ID | ENSG00000174944 |
| UniProt ID | Q9BXC1 |
| OMIM ID | 612008 |
| HGNC ID | 4512 |
| Aliases | H963, MGC119427, MGC119428 |
Description
GPR171 is a member of the G protein-coupled receptor family, specifically the class A rhodopsin-like receptors. It is an orphan receptor whose endogenous ligand is not fully characterized, though it has been shown to bind the neuropeptide big dynorphin. GPR171 is involved in modulating pain, reward, and immune responses. The gene is located on chromosome 3q25.1 and encodes a 321-amino acid protein with seven transmembrane domains.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Pain disorders | Modulation of nociception via big dynorphin binding | PMID: 23246003 |
| Substance use disorders | Involvement in reward pathways | PMID: 25698754 |
| Immune-related conditions | Expression in immune cells suggests role in inflammation | PMID: 20628086 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Spleen | 8.3 | Low |
| Lung | 6.1 | Low |
| Testis | 4.7 | Low |
| Kidney | 3.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.0 | Overexpressed in recombinant studies |
| Jurkat | 9.8 | Endogenous expression |
| SH-SY5Y | 7.2 | Neuronal model |
| THP-1 | 5.5 | Monocytic cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Cys) | Missense | <0.01% | Unknown |
| c.245G>A (p.Arg82His) | Missense | <0.01% | Unknown |
| c.568A>G (p.Ile190Val) | Missense | 0.02% | Likely benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • signal transducer activity |
| • plasma membrane | • integral component of membrane |
| • G protein-coupled receptor signaling pathway |
Pathways
• GPCR downstream signaling
• Neuroactive ligand-receptor interaction
Protein Summary
GPR171 is a 321-amino acid orphan GPCR with seven transmembrane helices. It is expressed in brain, spleen, and immune cells. The receptor couples to Gi/o proteins, inhibiting cAMP production. It is activated by big dynorphin, a prodynorphin-derived peptide, and modulates pain and reward signaling. Structural studies indicate a conserved orthosteric binding pocket typical of class A GPCRs.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPR171 Knockout HEK293 Cell Line | EDJ-KQ9077 | Human | 29909 | Details Get a Quote |
| GPR171 Knockout HeLa Cell Line | EDJ-KQ56119 | Human | 29909 | Details Get a Quote |
| GPR171 Knockout A-549 Cell Line | EDJ-KQ64605 | Human | 29909 | Details Get a Quote |
| GPR171 Knockout HCT 116 Cell Line | EDJ-KQ73057 | Human | 29909 | Details Get a Quote |
