GPR15LG
G Protein-Coupled Receptor 15 Ligand
Gene Information Card
| Symbol | GPR15LG |
|---|---|
| Full Name | G protein-coupled receptor 15 ligand |
| Gene Type | protein-coding |
| Chromosomal Location | 10q22.1 |
| NCBI Gene ID | 285203 ncbi.nlm.nih.gov/gene/285203 |
| Ensembl ID | ENSG00000185303 |
| UniProt ID | Q6UY14 |
| OMIM ID | 617542 |
| HGNC ID | 33832 |
| Aliases | C10orf99, AP-57, GPR15L, UNQ3038 |
Description
GPR15LG (G protein-coupled receptor 15 ligand) encodes a secreted protein that acts as a ligand for the orphan G protein-coupled receptor GPR15. It is involved in immune regulation, particularly in T-cell homing and mucosal immunity. The gene is located on chromosome 10q22.1 and is expressed in various tissues, with highest levels in the colon and small intestine.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Inflammatory Bowel Disease | GPR15LG-GPR15 signaling modulates T-cell trafficking to the gut; dysregulation may contribute to IBD pathogenesis. | PMID: 27559042 |
| Colorectal Cancer | Altered GPR15LG expression may influence tumor microenvironment and immune evasion. | PMID: 30349073 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Colon | 12.5 | Medium |
| Small Intestine | 10.2 | Medium |
| Appendix | 8.9 | Medium |
| Lung | 3.1 | Low |
| Spleen | 2.5 | Low |
| Liver | 1.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Caco-2 | 15.3 | Colorectal adenocarcinoma cell line |
| HT-29 | 11.8 | Colorectal adenocarcinoma cell line |
| A549 | 2.1 | Lung carcinoma cell line |
| HepG2 | 0.9 | Hepatocellular carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.200C>T (p.Pro67Leu) | Missense | <0.01% | Unknown functional impact |
| c.346G>A (p.Gly116Arg) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in COSMIC or ClinVar.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor binding (GO:0001664) | • extracellular region (GO:0005576) |
| • chemokine activity (GO:0008009) |
Pathways
• GPR15 signaling pathway
• Immune system - chemokine receptors bind chemokines
Protein Summary
GPR15LG is a secreted ligand for GPR15, a G protein-coupled receptor. The protein is approximately 15 kDa and contains a signal peptide. It is expressed predominantly in the gastrointestinal tract and plays a role in recruiting T cells to mucosal sites. Its structure includes a conserved chemokine-like fold.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPR15LG Knockout HEK293 Cell Line | EDJ-KQ13655 | Human | 387695 | Details Get a Quote |
| GPR15LG Knockout HeLa Cell Line | EDJ-KQ59982 | Human | 387695 | Details Get a Quote |
| GPR15LG Knockout A-549 Cell Line | EDJ-KQ68444 | Human | 387695 | Details Get a Quote |
| GPR15LG Knockout HCT 116 Cell Line | EDJ-KQ76821 | Human | 387695 | Details Get a Quote |
