GPR158: Orphan G Protein-Coupled Receptor 158
A regulator of neuronal signaling and potential oncogene in cancer
Gene Information Card
| Symbol | GPR158 |
|---|---|
| Full Name | G protein-coupled receptor 158 |
| Gene Type | protein-coding |
| Chromosomal Location | 10p12.1 |
| NCBI Gene ID | 57512 ncbi.nlm.nih.gov/gene/57512 |
| Ensembl ID | ENSG00000148737 |
| UniProt ID | Q5T848 |
| OMIM ID | 614212 |
| HGNC ID | 23689 |
| Aliases | KIAA1136, MGC138499 |
Description
GPR158 is an orphan G protein-coupled receptor (GPCR) that is highly expressed in the brain, particularly in the hippocampus and cortex. It plays a role in neuronal signaling, synaptic plasticity, and has been implicated in cancer progression, including prostate and breast cancer. GPR158 is known to interact with RGS7 and regulate G protein signaling.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | Overexpression of GPR158 promotes cell proliferation and invasion through GPCR signaling pathways. | PMID: 25977332 |
| Breast cancer | GPR158 is upregulated and associated with poor prognosis; may activate MAPK/ERK signaling. | PMID: 30518678 |
| Major depressive disorder | Genetic variants in GPR158 are associated with altered stress response and depression risk. | PMID: 28472653 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | High |
| Cerebral cortex | 15.2 | High |
| Hippocampus | 18.0 | High |
| Testis | 3.1 | Medium |
| Prostate | 2.8 | Medium |
| Breast | 1.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PC-3 (prostate cancer) | 8.5 | Overexpressed |
| MCF-7 (breast cancer) | 6.2 | Moderate expression |
| SH-SY5Y (neuroblastoma) | 10.1 | High expression |
| HEK293 (embryonic kidney) | 2.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Cys) | Missense | 0.01% | Unknown functional impact |
| c.567G>A (p.Trp189*) | Nonsense | <0.01% | Loss of function |
| c.890_891insA | Frameshift | <0.01% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations in GPR158 are predicted to result in truncated or non-functional protein.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • signal transduction |
| • plasma membrane | • synaptic signaling |
| • regulation of G protein-coupled receptor signaling pathway |
Pathways
• GPCR signaling
• RGS7 complex
• MAPK/ERK signaling
Protein Summary
GPR158 is a 7-transmembrane domain orphan GPCR of approximately 120 kDa. It is predominantly expressed in the brain and forms a complex with RGS7 and Gβ5 to modulate G protein signaling. The protein is involved in neuronal development and synaptic function. In cancer, GPR158 overexpression correlates with aggressive disease and may serve as a therapeutic target.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPR158 Knockout HEK293 Cell Line | EDJ-KQ13669 | Human | 57512 | Details Get a Quote |
| GPR158 Knockout HCT 116 Cell Line | EDJ-KQ43363 | Human | 57512 | Details Get a Quote |
| GPR158 Knockout HeLa Cell Line | EDJ-KQ56854 | Human | 57512 | Details Get a Quote |
| GPR158 Knockout A-549 Cell Line | EDJ-KQ65367 | Human | 57512 | Details Get a Quote |
