GPR157: G Protein-Coupled Receptor 157
Orphan GPCR with potential roles in neurodevelopment and cancer
Gene Information Card
| Symbol | GPR157 |
|---|---|
| Full Name | G protein-coupled receptor 157 |
| Gene Type | protein-coding |
| Chromosomal Location | 1p36.22 |
| NCBI Gene ID | 80045 ncbi.nlm.nih.gov/gene/80045 |
| Ensembl ID | ENSG00000180758 |
| UniProt ID | Q5U3X3 |
| OMIM ID | 616999 |
| HGNC ID | 23687 |
| Aliases | GPCR157, GPR157_HUMAN |
Description
GPR157 is an orphan G protein-coupled receptor (GPCR) encoded by the GPR157 gene located on chromosome 1p36.22. It is predicted to be a member of the class A rhodopsin-like GPCR family. The receptor is expressed in various tissues, with notable levels in the brain, and has been implicated in neurodevelopmental processes and certain cancers. Its endogenous ligand remains unidentified.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Glioblastoma | Potential role in tumor progression via GPCR signaling | Expression data from TCGA; functional studies limited |
| Neurodevelopmental disorders | Possible involvement in neuronal differentiation | Expression in fetal brain; no direct mutation evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 4.2 | Medium |
| Testis | 2.8 | Low |
| Lung | 1.5 | Low |
| Liver | 0.9 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y | 3.1 | Neuroblastoma cell line |
| U87MG | 2.5 | Glioblastoma cell line |
| HEK293 | 1.8 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | <0.01% | Unknown; predicted benign |
| c.452G>A (p.Arg151His) | Missense | <0.01% | Unknown; predicted tolerated |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor signaling pathway | • plasma membrane |
| • signal transduction |
Pathways
• GPCR downstream signaling
Protein Summary
GPR157 is a 377-amino acid orphan GPCR with seven transmembrane domains. It is localized to the plasma membrane and likely couples to G proteins to modulate intracellular signaling. The protein shares homology with other class A GPCRs but lacks a known ligand. Expression data suggest roles in neural tissues and potential involvement in cancer biology.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPR157 Knockout HEK293 Cell Line | EDJ-KQ9438 | Human | 80045 | Details Get a Quote |
| GPR157 Knockout A-549 Cell Line | EDJ-KQ36118 | Human | 80045 | Details Get a Quote |
| GPR157 Knockout HCT 116 Cell Line | EDJ-KQ36119 | Human | 80045 | Details Get a Quote |
| GPR157 Knockout HeLa Cell Line | EDJ-KQ34872 | Human | 80045 | Details Get a Quote |
