GPR155
G Protein-Coupled Receptor 155
Gene Information Card
| Symbol | GPR155 |
|---|---|
| Full Name | G protein-coupled receptor 155 |
| Gene Type | protein-coding |
| Chromosomal Location | 2q31.1 |
| NCBI Gene ID | 151556 ncbi.nlm.nih.gov/gene/151556 |
| Ensembl ID | ENSG00000163328 |
| UniProt ID | Q7Z3Z0 |
| OMIM ID | 616764 |
| HGNC ID | 23037 |
| Aliases | GPR155, MGC131938, MGC148091 |
Description
GPR155 encodes a member of the G protein-coupled receptor family. The protein is predicted to be a multi-pass membrane receptor involved in signal transduction. Its specific ligands and physiological functions remain under investigation, but expression data suggest roles in neuronal and endocrine tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Autism spectrum disorder | Potential involvement in synaptic signaling; rare variants observed | ClinVar |
| Schizophrenia | Association with genetic variants in GWAS | NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain (cerebellum) | 12.5 | Medium |
| Testis | 8.3 | Low |
| Adrenal gland | 6.1 | Low |
| Thyroid | 5.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 15.2 | Neuronal model |
| HEK293 (embryonic kidney) | 9.8 | Common expression system |
| HepG2 (hepatocellular carcinoma) | 4.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Cys) | Missense | <0.01% | Unknown functional impact |
| c.567_568del (p.Glu189fs) | Frameshift | Rare | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense variants likely lead to truncated or absent protein.
Gain of Function (GOF)
No gain-of-function variants reported.
Dominant Negative (DN)
No dominant-negative mechanisms described.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor signaling pathway | • integral component of membrane |
| • signal transduction |
Pathways
• GPCR downstream signaling
Protein Summary
GPR155 is a 7-transmembrane domain G protein-coupled receptor of unknown ligand specificity. It is expressed in brain, testis, and endocrine tissues. Its exact signaling cascade and physiological roles are not fully characterized, but it may modulate neuronal and endocrine functions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPR155 Knockout HEK293 Cell Line | EDJ-KQ11342 | Human | 151556 | Details Get a Quote |
| GPR155 Knockout A-549 Cell Line | EDJ-KQ39508 | Human | 151556 | Details Get a Quote |
| GPR155 Knockout HCT 116 Cell Line | EDJ-KQ39509 | Human | 151556 | Details Get a Quote |
| GPR155 Knockout HeLa Cell Line | EDJ-KQ39510 | Human | 151556 | Details Get a Quote |
