GPR153: G Protein-Coupled Receptor 153
Orphan GPCR with potential roles in neurodevelopment and cancer
Gene Information Card
| Symbol | GPR153 |
|---|---|
| Full Name | G protein-coupled receptor 153 |
| Gene Type | protein-coding |
| Chromosomal Location | 1p21.3 |
| NCBI Gene ID | 387509 ncbi.nlm.nih.gov/gene/387509 |
| Ensembl ID | ENSG00000158292 |
| UniProt ID | Q6NV75 |
| OMIM ID | 614531 |
| HGNC ID | 23687 |
| Aliases | PGR1, GPCR153 |
Description
GPR153 is an orphan G protein-coupled receptor (GPCR) encoded by the GPR153 gene located on chromosome 1p21.3. The protein belongs to the class A rhodopsin-like GPCR family. Its endogenous ligand remains unknown, but expression data suggest roles in neurodevelopment and potential involvement in cancer. GPR153 is conserved across vertebrates and is predominantly expressed in brain tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Glioblastoma | Overexpression may contribute to tumor growth | COSMIC; PMID: 25691885 |
| Colorectal cancer | Altered expression in tumor vs normal tissue | COSMIC; PMID: 27149842 |
| Neurodevelopmental disorders | Expression in fetal brain suggests role in development | UniProt; NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Cerebral cortex | 12.3 | Medium |
| Cerebellum | 10.8 | Medium |
| Hippocampus | 9.5 | Medium |
| Testis | 6.2 | Low |
| Adrenal gland | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 8.7 | Neuronal model |
| U87MG (glioblastoma) | 11.4 | Overexpressed |
| HEK293 (embryonic kidney) | 3.2 | Low endogenous expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | <0.01% | Unknown; rare population variant |
| c.452G>A (p.Arg151Gln) | Missense | <0.01% | Unknown; rare population variant |
| c.784_786del (p.Lys262del) | In-frame deletion | <0.01% | Unknown; rare population variant |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor signaling pathway (GO:0007186) | • plasma membrane (GO:0005886) |
| • integral component of membrane (GO:0016021) | • signal transduction (GO:0007165) |
Pathways
• GPCR downstream signaling (Reactome: R-HSA-388396)
• Class A/1 (Rhodopsin-like receptors) (Reactome: R-HSA-373076)
Protein Summary
GPR153 is a 377-amino acid orphan GPCR with seven transmembrane domains. It is predicted to couple to G proteins, though the specific Gα subtype is unknown. The protein is localized to the plasma membrane and is highly expressed in brain regions, suggesting a role in neuronal signaling. No endogenous ligand has been identified, and functional studies are limited.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPR153 Knockout HEK293 Cell Line | EDJ-KQ12912 | Human | 387509 | Details Get a Quote |
| GPR153 Knockout HCT 116 Cell Line | EDJ-KQ43360 | Human | 387509 | Details Get a Quote |
| GPR153 Knockout HeLa Cell Line | EDJ-KQ43361 | Human | 387509 | Details Get a Quote |
| GPR153 Knockout A-549 Cell Line | EDJ-KQ68438 | Human | 387509 | Details Get a Quote |
