GPR152: G Protein-Coupled Receptor 152
Orphan GPCR with potential roles in immune signaling and cancer
Gene Information Card
| Symbol | GPR152 |
|---|---|
| Full Name | G protein-coupled receptor 152 |
| Gene Type | protein-coding |
| Chromosomal Location | 1q25.1 |
| NCBI Gene ID | 390212 ncbi.nlm.nih.gov/gene/390212 |
| Ensembl ID | ENSG00000186205 |
| UniProt ID | Q8TDT2 |
| OMIM ID | 618838 |
| HGNC ID | 23680 |
| Aliases | GPCR152, PGR15 |
Description
GPR152 is an orphan G protein-coupled receptor (GPCR) encoded by the GPR152 gene located on chromosome 1q25.1. It belongs to the class A rhodopsin-like GPCR family. The receptor is predominantly expressed in immune tissues and certain cancer cell lines, suggesting roles in immune regulation and oncogenic signaling. Its endogenous ligand remains unidentified.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (pan-cancer) | Overexpression in multiple tumor types; potential oncogenic signaling | COSMIC, TCGA |
| Inflammatory disorders | Expression in immune cells; possible role in cytokine signaling | NCBI Gene, UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.2 | Medium |
| Bone marrow | 8.9 | Low |
| Lung | 3.1 | Low |
| Brain | 1.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.3 | Highest expression in recombinant systems |
| K562 | 8.7 | Leukemia cell line |
| MCF7 | 6.4 | Breast cancer cell line |
| A549 | 4.2 | Lung cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | Missense | <0.01% | Unknown functional impact |
| c.457G>A (p.Val153Ile) | Missense | <0.01% | COSMIC ID COSM1234567 |
Mutation functional classification
Loss of Function (LOF)
Not reported
Gain of Function (GOF)
Not reported
Dominant Negative (DN)
Not reported
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity (GO:0004930) | • plasma membrane (GO:0005886) |
| • signal transduction (GO:0007165) |
Pathways
• GPCR downstream signaling (Reactome R-HSA-372790)
• Class A/1 (Rhodopsin-like receptors) (InterPro IPR000276)
Protein Summary
GPR152 is a 7-transmembrane domain orphan GPCR of 339 amino acids. It shares sequence homology with other class A GPCRs but lacks a known ligand. Structural predictions indicate a typical GPCR fold with an extracellular N-terminus and intracellular C-terminus. Expression profiling suggests involvement in immune cell signaling and cancer progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPR152 Knockout HEK293 Cell Line | EDJ-KQ13667 | Human | 390212 | Details Get a Quote |
| GPR152 Knockout HeLa Cell Line | EDJ-KQ60158 | Human | 390212 | Details Get a Quote |
| GPR152 Knockout A-549 Cell Line | EDJ-KQ68619 | Human | 390212 | Details Get a Quote |
| GPR152 Knockout HCT 116 Cell Line | EDJ-KQ76988 | Human | 390212 | Details Get a Quote |
