GPR150: G Protein-Coupled Receptor 150
Orphan GPCR with potential roles in cellular signaling and disease
Gene Information Card
| Symbol | GPR150 |
|---|---|
| Full Name | G protein-coupled receptor 150 |
| Gene Type | protein-coding |
| Chromosomal Location | 5q31.3 |
| NCBI Gene ID | 285601 ncbi.nlm.nih.gov/gene/285601 |
| Ensembl ID | ENSG00000164136 |
| UniProt ID | Q8TCC7 |
| OMIM ID | 616543 |
| HGNC ID | 23630 |
| Aliases | PGR15, GPCR150 |
Description
GPR150 is an orphan G protein-coupled receptor (GPCR) with no known endogenous ligand. It is primarily expressed in the brain and testis, and its function remains under investigation. The gene is located on chromosome 5q31.3 and encodes a 7-transmembrane domain receptor. GPR150 may be involved in neuroendocrine signaling and has been implicated in certain cancers and neurological disorders based on expression and mutation data.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression in tumor tissues; potential role in cell proliferation | COSMIC, NCBI GEO |
| Glioblastoma | Altered expression in glioma stem cells | NCBI GEO, literature |
| Schizophrenia | Genetic association in GWAS studies | OMIM, ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 2.1 | Low |
| Testis | 1.8 | Low |
| Adipose tissue | 0.5 | Not detected |
| Heart | 0.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.8 | Low expression; used for heterologous expression studies |
| SH-SY5Y | 1.2 | Neuroblastoma cell line; moderate expression |
| MCF7 | 2.5 | Breast cancer cell line; elevated expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | Missense | <0.01% | Unknown; predicted benign by SIFT |
| c.250G>A (p.Gly84Ser) | Missense | <0.01% | Unknown; predicted damaging by PolyPhen-2 |
| c.421_423del (p.Phe141del) | In-frame deletion | <0.01% | Unknown; may affect receptor structure |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • plasma membrane |
| • signal transduction | • cell surface receptor signaling pathway |
Pathways
• GPCR downstream signaling
• cAMP signaling pathway (predicted)
Protein Summary
GPR150 is a 7-transmembrane domain orphan GPCR of 374 amino acids. It shares homology with other class A rhodopsin-like GPCRs. The protein is predicted to couple to G proteins, but its specific signaling cascade and ligand remain unknown. Structural studies suggest a conserved DRY motif and potential palmitoylation sites.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPR150 Knockout HEK293 Cell Line | EDJ-KQ13666 | Human | 285601 | Details Get a Quote |
| GPR150 Knockout HeLa Cell Line | EDJ-KQ59522 | Human | 285601 | Details Get a Quote |
| GPR150 Knockout A-549 Cell Line | EDJ-KQ67991 | Human | 285601 | Details Get a Quote |
| GPR150 Knockout HCT 116 Cell Line | EDJ-KQ76369 | Human | 285601 | Details Get a Quote |
