GPR15: G Protein-Coupled Receptor 15
A chemokine-like receptor involved in immune regulation and HIV susceptibility
Gene Information Card
| Symbol | GPR15 |
|---|---|
| Full Name | G protein-coupled receptor 15 |
| Gene Type | protein-coding |
| Chromosomal Location | 3q11.2 |
| NCBI Gene ID | 2838 ncbi.nlm.nih.gov/gene/2838 |
| Ensembl ID | ENSG00000154165 |
| UniProt ID | P49685 |
| OMIM ID | 601166 |
| HGNC ID | 4469 |
| Aliases | BOB, GPR15L, HIV-1 coreceptor |
Description
GPR15 (G protein-coupled receptor 15) is a member of the rhodopsin-like G protein-coupled receptor family. It functions as a chemokine-like receptor and serves as a coreceptor for HIV-1 entry, particularly for certain viral strains. GPR15 is expressed on various immune cells and is involved in lymphocyte homing and inflammatory responses. Its ligand, GPR15L (also known as C10orf99), modulates immune cell trafficking.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| HIV-1 infection | GPR15 acts as an alternative coreceptor for HIV-1 entry into CD4+ T cells | PMID: 8626455 |
| Inflammatory bowel disease | GPR15 expression on T cells is associated with colonic inflammation | PMID: 25731159 |
| Psoriasis | GPR15L/GPR15 signaling implicated in skin inflammation | PMID: 28386017 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Colon | 12.5 | Medium |
| Small intestine | 10.2 | Medium |
| Spleen | 8.9 | Medium |
| Lung | 6.3 | Low |
| Skin | 5.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Jurkat (T-cell leukemia) | 15.3 | High expression |
| THP-1 (monocytic leukemia) | 8.7 | Moderate expression |
| HeLa (cervical carcinoma) | 2.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | 0.02% (gnomAD) | Unknown functional effect |
| c.487G>A (p.Val163Ile) | Missense | 0.01% (gnomAD) | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in GPR15.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in GPR15.
Dominant Negative (DN)
No dominant-negative mutations reported in GPR15.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • chemokine receptor activity |
| • coreceptor activity | • plasma membrane |
| • integral component of membrane | • signal transduction |
| • cell chemotaxis | • inflammatory response |
Pathways
• HIV-1 entry pathway
• Chemokine signaling pathway
• G alpha (i) signaling events
Protein Summary
GPR15 is a 360-amino acid transmembrane protein with seven membrane-spanning domains typical of G protein-coupled receptors. It is expressed on the surface of immune cells, particularly T lymphocytes, and mediates chemotactic responses. The receptor couples to Gi/o proteins and activates downstream signaling pathways including MAPK and PI3K. GPR15 is also exploited by HIV-1 as an alternative coreceptor for viral entry.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPR15 Knockout HEK293 Cell Line | EDJ-KQ3641 | Human | 2838 | Details Get a Quote |
| GPR151 Knockout HEK293 Cell Line | EDJ-KQ9339 | Human | 134391 | Details Get a Quote |
| GPR157 Knockout HEK293 Cell Line | EDJ-KQ9438 | Human | 80045 | Details Get a Quote |
| GPR155 Knockout HEK293 Cell Line | EDJ-KQ11342 | Human | 151556 | Details Get a Quote |
| GPR153 Knockout HEK293 Cell Line | EDJ-KQ12912 | Human | 387509 | Details Get a Quote |
| GPR15LG Knockout HEK293 Cell Line | EDJ-KQ13655 | Human | 387695 | Details Get a Quote |
| GPR150 Knockout HEK293 Cell Line | EDJ-KQ13666 | Human | 285601 | Details Get a Quote |
| GPR152 Knockout HEK293 Cell Line | EDJ-KQ13667 | Human | 390212 | Details Get a Quote |
| GPR156 Knockout HEK293 Cell Line | EDJ-KQ13668 | Human | 165829 | Details Get a Quote |
| GPR158 Knockout HEK293 Cell Line | EDJ-KQ13669 | Human | 57512 | Details Get a Quote |
| GPR157 Knockout A-549 Cell Line | EDJ-KQ36118 | Human | 80045 | Details Get a Quote |
| GPR157 Knockout HCT 116 Cell Line | EDJ-KQ36119 | Human | 80045 | Details Get a Quote |
| GPR15 Knockout HCT 116 Cell Line | EDJ-KQ24220 | Human | 2838 | Details Get a Quote |
| GPR157 Knockout HeLa Cell Line | EDJ-KQ34872 | Human | 80045 | Details Get a Quote |
| GPR155 Knockout A-549 Cell Line | EDJ-KQ39508 | Human | 151556 | Details Get a Quote |
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