GPR146
G Protein-Coupled Receptor 146
Gene Information Card
| Symbol | GPR146 |
|---|---|
| Full Name | G protein-coupled receptor 146 |
| Gene Type | protein-coding |
| Chromosomal Location | 7p22.3 |
| NCBI Gene ID | 115330 ncbi.nlm.nih.gov/gene/115330 |
| Ensembl ID | ENSG00000164849 |
| UniProt ID | Q96CH1 |
| OMIM ID | 616477 |
| HGNC ID | 23633 |
| Aliases | PGR8, GPCR146 |
Description
GPR146 is an orphan G protein-coupled receptor (GPCR) that is highly conserved across vertebrates. It is implicated in lipid metabolism and cholesterol homeostasis. Genome-wide association studies have linked variants near GPR146 to plasma lipid levels and cardiovascular risk. The receptor is expressed in multiple tissues, including liver and adipose, and may modulate hepatic very low-density lipoprotein (VLDL) secretion.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hyperlipidemia, susceptibility to | GPR146 variants influence hepatic VLDL secretion and plasma lipid levels | GWAS (PMID: 30275531) |
| Coronary artery disease | Genetic variation at the GPR146 locus is associated with CAD risk | GWAS (PMID: 30275531) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 8.2 | Medium |
| Adipose tissue | 5.1 | Low |
| Pancreas | 4.3 | Low |
| Small intestine | 3.9 | Low |
| Spleen | 2.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 6.5 | Hepatocellular carcinoma cell line |
| 3T3-L1 | 4.8 | Adipocyte precursor cell line |
| Caco-2 | 3.2 | Colorectal adenocarcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs1997243 | SNP (intronic) | 0.15 (European) | Associated with altered LDL cholesterol levels |
| rs11556924 | SNP (intronic) | 0.10 (European) | Associated with coronary artery disease risk |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity (GO:0004930) | • plasma membrane (GO:0005886) |
| • signal transduction (GO:0007165) | • receptor activity (GO:0004872) |
Pathways
• GPCR downstream signaling
• Lipid metabolism
Protein Summary
GPR146 is a 333-amino acid orphan GPCR with seven transmembrane domains. It is predominantly expressed in liver and adipose tissue. The receptor is thought to couple to Gαi/o proteins, inhibiting adenylyl cyclase and reducing cAMP levels. Functional studies suggest GPR146 regulates hepatic VLDL secretion, thereby influencing plasma triglyceride and cholesterol levels. Its endogenous ligand remains unknown.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPR146 Knockout HEK293 Cell Line | EDJ-KQ7516 | Human | 115330 | Details Get a Quote |
| GPR146 Knockout HCT 116 Cell Line | EDJ-KQ31438 | Human | 115330 | Details Get a Quote |
| GPR146 Knockout HeLa Cell Line | EDJ-KQ57949 | Human | 115330 | Details Get a Quote |
| GPR146 Knockout A-549 Cell Line | EDJ-KQ66440 | Human | 115330 | Details Get a Quote |
