GPR132: G Protein-Coupled Receptor 132
A proton-sensing receptor involved in immune regulation and cancer
Gene Information Card
| Symbol | GPR132 |
|---|---|
| Full Name | G protein-coupled receptor 132 |
| Gene Type | protein-coding |
| Chromosomal Location | 14q32.33 |
| NCBI Gene ID | 29933 ncbi.nlm.nih.gov/gene/29933 |
| Ensembl ID | ENSG00000100814 |
| UniProt ID | Q9UNW8 |
| OMIM ID | 606125 |
| HGNC ID | 4465 |
| Aliases | G2A |
Description
GPR132 (G2A) is a proton-sensing G protein-coupled receptor that responds to extracellular acidic pH. It plays roles in immune cell activation, macrophage function, and tumor microenvironment modulation. The receptor is implicated in inflammatory diseases and cancer progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression promotes tumor growth and metastasis | PMID: 21947068 |
| Atherosclerosis | Regulates macrophage foam cell formation | PMID: 11567032 |
| Autoimmune diseases | Modulates T-cell responses | PMID: 12538644 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 12.5 | Medium |
| Lung | 8.3 | Low |
| Whole blood | 6.1 | Low |
| Lymph node | 15.2 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 18.4 | High expression |
| Jurkat (T-cell) | 22.1 | High expression |
| MCF7 (breast cancer) | 9.7 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | Missense | 0.01% | Unknown functional effect |
| c.457G>A (p.Glu153Lys) | Missense | 0.005% | Reported in COSMIC |
Mutation functional classification
Loss of Function (LOF)
Not well characterized; some missense variants may impair receptor signaling
Gain of Function (GOF)
Not reported
Dominant Negative (DN)
Not reported
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity (GO:0004930) | • proton-sensing receptor activity (GO:0038026) |
| • plasma membrane (GO:0005886) | • immune response (GO:0006955) |
Pathways
• Proton-sensing receptor signaling
• G alpha (q) signaling events
Protein Summary
GPR132 is a 380-amino acid integral membrane protein with seven transmembrane domains. It functions as a proton sensor, coupling to G proteins to activate downstream signaling pathways such as calcium mobilization and MAPK activation. It is expressed predominantly in lymphoid tissues and immune cells.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPR132 Knockout HEK293 Cell Line | EDJ-KQ9089 | Human | 29933 | Details Get a Quote |
| GPR132 Knockout HeLa Cell Line | EDJ-KQ56123 | Human | 29933 | Details Get a Quote |
| GPR132 Knockout A-549 Cell Line | EDJ-KQ64609 | Human | 29933 | Details Get a Quote |
| GPR132 Knockout HCT 116 Cell Line | EDJ-KQ73061 | Human | 29933 | Details Get a Quote |
