GPR108: G Protein-Coupled Receptor 108
A multi-pass membrane protein with roles in immune signaling and viral entry
Gene Information Card
| Symbol | GPR108 |
|---|---|
| Full Name | G protein-coupled receptor 108 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.33 |
| NCBI Gene ID | 80827 ncbi.nlm.nih.gov/gene/80827 |
| Ensembl ID | ENSG00000104884 |
| UniProt ID | Q9BZJ0 |
| OMIM ID | 618688 |
| HGNC ID | 17831 |
| Aliases | GPR108, LUSTR, GPCR108 |
Description
GPR108 encodes a member of the G protein-coupled receptor family, characterized by seven transmembrane domains. The protein is involved in immune modulation and acts as a host factor for certain viral infections, including adeno-associated virus (AAV) entry. It is broadly expressed in lymphoid tissues and plays a role in B-cell and T-cell signaling.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lung cancer | Altered expression; potential oncogenic role | COSMIC mutation data |
| Immune system disorders | Modulation of immune receptor signaling | NCBI GeneRIF |
| Viral infection (AAV) | Required for AAV transduction | PubMed studies |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 11.8 | Medium |
| Lung | 9.2 | Medium |
| Bone marrow | 8.7 | Low |
| Brain | 3.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.2 | High expression |
| Jurkat | 13.8 | High expression |
| HeLa | 10.5 | Medium expression |
| A549 | 8.9 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100G>A (p.Gly34Arg) | Missense | 0.02% | Unknown functional impact |
| c.455C>T (p.Pro152Leu) | Missense | 0.01% | Reported in COSMIC |
| c.789_790insA | Frameshift | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense variants likely lead to truncated protein and loss of receptor function.
Gain of Function (GOF)
Not well characterized; some missense variants may alter signaling.
Dominant Negative (DN)
No evidence currently available.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor signaling pathway | • integral component of membrane |
| • immune response | • viral entry into host cell |
Pathways
• GPCR signaling (generic)
• AAV infection pathway
Protein Summary
GPR108 is a 7-transmembrane domain receptor expressed on the cell surface. It is involved in immune cell signaling and is exploited by adeno-associated virus for cellular entry. Its precise endogenous ligand remains unknown, but it is considered an orphan GPCR.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPR108 Knockout HEK293 Cell Line | EDJ-KQ3184 | Human | 56927 | Details Get a Quote |
| GPR108 Knockout HCT 116 Cell Line | EDJ-KQ23234 | Human | 56927 | Details Get a Quote |
| GPR108 Knockout A-549 Cell Line | EDJ-KQ24616 | Human | 56927 | Details Get a Quote |
| GPR108 Knockout HeLa Cell Line | EDJ-KQ24618 | Human | 56927 | Details Get a Quote |
