GPR107: G Protein-Coupled Receptor 107
A multi-pass membrane receptor involved in intracellular trafficking and potential tumor suppression
Gene Information Card
| Symbol | GPR107 |
|---|---|
| Full Name | G protein-coupled receptor 107 |
| Gene Type | protein-coding |
| Chromosomal Location | 9q34.3 |
| NCBI Gene ID | 57720 ncbi.nlm.nih.gov/gene/57720 |
| Ensembl ID | ENSG00000148303 |
| UniProt ID | Q5VW38 |
| OMIM ID | 618458 |
| HGNC ID | 17830 |
| Aliases | GPR107, FLJ10156, GPCR107 |
Description
GPR107 encodes a member of the G protein-coupled receptor family, characterized by seven transmembrane domains. The protein is localized to intracellular membranes and is involved in vesicle trafficking, Golgi function, and endosomal sorting. GPR107 has been implicated in tumor suppression and cellular stress responses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Loss of GPR107 expression may promote tumorigenesis through disrupted intracellular trafficking and signaling. | COSMIC; literature (PMID: 25691885) |
| Neurodevelopmental disorders | Rare variants in GPR107 have been reported in patients with intellectual disability and developmental delay. | ClinVar; literature (PMID: 28135719) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 10.2 | Medium |
| Testis | 15.8 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 14.2 | Moderate expression |
| HeLa | 9.7 | Low expression |
| A549 | 11.5 | Medium expression |
| MCF7 | 7.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015C>T (p.Arg339Trp) | Missense | <0.01% | Unknown functional impact; reported in ClinVar |
| c.1246G>A (p.Gly416Arg) | Missense | <0.01% | Likely benign; no known disease association |
Mutation functional classification
Loss of Function (LOF)
Not well characterized; reduced expression observed in some cancers.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity (GO:0004930) | • integral component of membrane (GO:0016021) |
| • intracellular signal transduction (GO:0035556) | • Golgi apparatus (GO:0005794) |
| • endosome (GO:0005768) |
Pathways
• GPCR signaling (Reactome: R-HSA-372790)
• Vesicle-mediated transport (Reactome: R-HSA-5653656)
Protein Summary
GPR107 is a 7-transmembrane G protein-coupled receptor predominantly localized to intracellular membranes such as Golgi and endosomes. It is involved in vesicle trafficking and may act as a tumor suppressor. Expression is highest in testis and brain. Mutations are rare and mostly of unknown significance.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPR107 Knockout HEK293 Cell Line | EDJ-KQ12906 | Human | 57720 | Details Get a Quote |
| GPR107 Knockout A-549 Cell Line | EDJ-KQ43349 | Human | 57720 | Details Get a Quote |
| GPR107 Knockout HCT 116 Cell Line | EDJ-KQ43350 | Human | 57720 | Details Get a Quote |
| GPR107 Knockout HeLa Cell Line | EDJ-KQ43351 | Human | 57720 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
